{"id":"W2576666433","doi":"10.1093/hmg/ddw434","title":"Immune dysregulation may contribute to disease pathogenesis in spinal muscular atrophy mice","year":2016,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Biology; Spinal muscular atrophy; SMA*; Immune system; Neuroinflammation; Pathogenesis; Spleen; Genetically modified mouse; Neurodegeneration; Population; Immune dysregulation; Atrophy; Immunology; Pathology; Transgene; Disease; Inflammation; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002099013,0.0008238841,0.0003620411,0.00106104,0.0002639939,0.0004559939,0.000220748,0.0007755428,0.002822154],"category_scores_gemma":[0.0001410648,0.0002832866,0.000408306,0.0002615003,0.0003945683,0.000345861,0.000421711,0.001094257,0.0006471457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002711487,"about_ca_system_score_gemma":0.000212002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002431273,"about_ca_topic_score_gemma":0.0004262135,"domain_scores_codex":[0.9997362,0.00006326361,0.00003371866,0.00007630437,0.00004400032,0.00004644241],"domain_scores_gemma":[0.9997823,0.00002480678,0.00007318741,0.00001828443,0.00001802752,0.00008349948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003624366,0.00007323059,0.001103272,0.00006026145,0.00001261855,0.0002453758,0.00003642227,0.00006562844,0.9956644,0.000168428,0.00006675877,0.002141081],"study_design_scores_gemma":[0.0002232516,0.002114624,0.1335063,0.0001705716,0.0001677082,0.005169457,0.0003704886,0.003839398,0.8422927,0.001174166,0.01093468,0.00003677199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920713,0.002313157,0.002208713,0.000239382,0.00004911727,0.00004141417,0.0007813211,0.000163022,0.00213256],"genre_scores_gemma":[0.9897209,0.001548415,0.002975156,0.0002000498,0.00002260416,0.000123007,0.0009038479,0.00005873527,0.004447248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002822154,"threshold_uncertainty_score":0.009441078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607136233596481,"score_gpt":0.3023953874356551,"score_spread":0.2863240250996903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}