{"id":"W2576734117","doi":"10.1016/j.jff.2016.12.022","title":"Milk-derived tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) differentially modulate angiotensin II effects on vascular smooth muscle cells","year":2017,"lang":"en","type":"article","venue":"Journal of Functional Foods","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Livestock and Meat Agency","keywords":"Angiotensin II; Vascular smooth muscle; Oxidative stress; Chemistry; Renin–angiotensin system; Inflammation; MAPK/ERK pathway; Vasoconstriction; Cell biology; Endocrinology; Signal transduction; Pharmacology; Internal medicine; Biology; Biochemistry; Medicine; Receptor; Smooth muscle; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009628799,0.0002080255,0.0002058132,0.0001124924,0.0001028616,0.0003128451,0.0001114239,0.0002539871,0.0009734909],"category_scores_gemma":[0.0001751983,0.000157033,0.0001938784,0.00008007594,0.0001912757,0.0003011763,0.0001792307,0.0005771671,0.0002107996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001385253,"about_ca_system_score_gemma":0.0001351772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002264734,"about_ca_topic_score_gemma":0.0002736301,"domain_scores_codex":[0.9999135,0.00002133564,0.000005902147,0.00001713386,0.0000102565,0.00003185617],"domain_scores_gemma":[0.999912,0.00002807358,0.00001366607,0.000005950291,0.000007978422,0.00003219852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008002967,0.00002137434,0.0001548366,0.00001840724,0.000003813862,0.00007333616,0.00001360582,0.00002642391,0.9977686,0.00005791832,0.00001481637,0.001046571],"study_design_scores_gemma":[0.00007449662,0.001027265,0.01332832,0.000007351381,0.00003974225,0.0002776067,0.000135614,0.0007218143,0.9833415,0.0001443456,0.0008966409,0.000005284841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997809,0.0006984877,0.0007429614,0.00005764167,0.0000247446,0.000007076863,0.00006264634,0.00000666159,0.0005908682],"genre_scores_gemma":[0.9971356,0.0005789066,0.0008504751,0.00005579752,0.00001580191,0.00001845638,0.0001240432,0.000007949678,0.00121292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009734909,"threshold_uncertainty_score":0.003256679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01831555712970788,"score_gpt":0.2415007591804429,"score_spread":0.2231852020507351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}