{"id":"W2576909123","doi":"10.1182/blood.v104.11.4939.4939","title":"The Effect of Increasing Zoledronic Acid Dose and Infusion Rate on Pharmacokinetics, Pharmacodynamics, and Renal Function in Patients with Multiple Myeloma.","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre","funders":"","keywords":"Medicine; Zoledronic acid; Pharmacokinetics; Cmax; Multiple myeloma; Regimen; Renal function; Adverse effect; Pharmacodynamics; Internal medicine; Urology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009479735,0.0003008113,0.0004473018,0.0001258004,0.0001094822,0.0004081807,0.0002402708,0.0003424921,0.0006321393],"category_scores_gemma":[0.002925632,0.0001728921,0.0003951877,0.0001718484,0.0001840143,0.0003434876,0.0001363816,0.0006501374,0.0001479289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003036648,"about_ca_system_score_gemma":0.000238038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002181682,"about_ca_topic_score_gemma":0.0002989185,"domain_scores_codex":[0.9995185,0.0002465042,0.00003782472,0.00006496365,0.00008561816,0.00004664262],"domain_scores_gemma":[0.9988267,0.0004710935,0.0004759929,0.00005363287,0.00003464734,0.0001378563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2430816,0.009562646,0.312676,0.0005474071,0.001643975,0.0004667999,0.0003419621,0.007379312,0.07281021,0.0001626071,0.00154888,0.3497786],"study_design_scores_gemma":[0.02248404,0.3290619,0.5929021,0.00008302466,0.001539594,0.001804612,0.0001603933,0.01770799,0.03038745,0.0003114202,0.003483905,0.00007356026],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979092,0.001325055,0.0002683807,0.00007654956,0.0000133142,0.00003989491,0.00005024841,0.00002411223,0.0002931854],"genre_scores_gemma":[0.9992608,0.0001798942,0.0003496715,0.00005470095,0.00001564789,0.00001939135,0.00004325353,0.000002799373,0.00007376312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009479735,"threshold_uncertainty_score":0.005013406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005394093303611121,"score_gpt":0.248952269548968,"score_spread":0.2435581762453568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}