{"id":"W2577361732","doi":"10.1182/blood.v112.11.189.189","title":"Activation of PP2A by FTY720 Inhibits Survival and Self-Renewal of the Ph(+) Chronic Myelogenous Leukemia (CML) CD34+/CD38− Stem Cell through the Simultaneous Suppression of BCR/ABL and BCR/ABL– independent Signals","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"","keywords":"CD38; Dasatinib; Progenitor cell; Cancer research; Chronic myelogenous leukemia; Stem cell; Biology; Clonogenic assay; Haematopoiesis; CD34; Imatinib; Imatinib mesylate; Leukemia; Immunology; Myeloid leukemia; Cell biology; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002591693,0.0003768934,0.0007359432,0.0000637156,0.0001907986,0.000009632523,0.0002504192,0.0002884415,0.00004776447],"category_scores_gemma":[0.00008009777,0.0002351395,0.0001385267,0.0002906132,0.0003490714,0.0001239598,0.000250791,0.0003515284,0.000002561562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004819476,"about_ca_system_score_gemma":0.00104399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001131124,"about_ca_topic_score_gemma":0.00006010073,"domain_scores_codex":[0.9972941,0.0002507462,0.0007336872,0.0004784731,0.0008447942,0.0003981811],"domain_scores_gemma":[0.9976375,0.0007086697,0.0006614614,0.0006859075,0.0001969761,0.0001094705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004752175,0.002175327,0.01706562,0.001086446,0.0007992848,0.00005307764,0.008477198,0.0007888115,0.9670556,0.00002914602,0.0002848023,0.001709473],"study_design_scores_gemma":[0.01187304,0.001075934,0.004024615,0.0004201324,0.0006789893,0.0002411042,0.0005924209,0.0003570945,0.980184,0.00003834208,0.0003036062,0.0002107375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933321,0.004183447,0.00001852022,0.00010816,0.0000959543,0.001172913,0.00009558231,0.00003273199,0.000960619],"genre_scores_gemma":[0.9974496,0.001734039,0.000106717,0.00003494841,0.00009795787,0.00002035619,0.00003321745,0.00005153206,0.0004715893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01312839,"threshold_uncertainty_score":0.9588711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192342116242778,"score_gpt":0.222397065891162,"score_spread":0.2104736447287342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}