{"id":"W2577361732","doi":"10.1182/blood.v112.11.189.189","title":"Activation of PP2A by FTY720 Inhibits Survival and Self-Renewal of the Ph(+) Chronic Myelogenous Leukemia (CML) CD34+/CD38− Stem Cell through the Simultaneous Suppression of BCR/ABL and BCR/ABL– independent Signals","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"","keywords":"CD38; Dasatinib; Progenitor cell; Cancer research; Chronic myelogenous leukemia; Stem cell; Biology; Clonogenic assay; Haematopoiesis; CD34; Imatinib; Imatinib mesylate; Leukemia; Immunology; Myeloid leukemia; Cell biology; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000138281,0.0003576209,0.0002325535,0.0001563054,0.0001587008,0.0002579393,0.0001517784,0.0001617402,0.0009239158],"category_scores_gemma":[0.00009460026,0.00008291571,0.0002100432,0.0001311313,0.0001909896,0.0001021128,0.0001356514,0.00043837,0.0002407753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002482701,"about_ca_system_score_gemma":0.0001809479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005303813,"about_ca_topic_score_gemma":0.001204063,"domain_scores_codex":[0.999887,0.00001776166,0.00001156849,0.00001462413,0.00003306695,0.00003604501],"domain_scores_gemma":[0.9999582,0.000007929604,0.000009364768,0.00000511926,0.000003231738,0.00001619802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002255541,0.00008043775,0.000174903,0.00003160049,0.000005698059,0.00003958769,0.000009452351,0.00009680443,0.9978597,0.00008199663,0.00008008481,0.001314228],"study_design_scores_gemma":[0.00005748071,0.0009381352,0.004937698,0.000004279961,0.00001837462,0.0002824313,0.0000171024,0.001345749,0.9908202,0.0000329647,0.001541667,0.000003801539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966332,0.001187635,0.0007558085,0.00006622806,0.00002835851,0.00002057088,0.0002382311,0.00006053457,0.001009381],"genre_scores_gemma":[0.9975555,0.0004351771,0.0004677849,0.00002211874,0.0000101871,0.00003042537,0.0002989561,0.000007598121,0.001172147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009239158,"threshold_uncertainty_score":0.003090739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192342116242778,"score_gpt":0.222397065891162,"score_spread":0.2104736447287342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}