{"id":"W2577607829","doi":"10.1016/j.neulet.2017.01.041","title":"Treatment of rats with the JAK-2 inhibitor fedratinib does not lead to experimental Wernicke’s encephalopathy","year":2017,"lang":"en","type":"article","venue":"Neuroscience Letters","topic":"Alcoholism and Thiamine Deficiency","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Thiamine; Medicine; Myelofibrosis; Encephalopathy; Adverse effect; Wernicke's encephalopathy; Ruxolitinib; Internal medicine; Pharmacology; Gastroenterology; Thiamine deficiency; Endocrinology; Bone marrow","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002832367,0.001431984,0.001524106,0.001469271,0.0005831323,0.0005805093,0.0007231554,0.001712906,0.004268804],"category_scores_gemma":[0.0005949675,0.0006174045,0.000786397,0.0004354515,0.001704496,0.00138817,0.000357862,0.002505439,0.001114046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006444118,"about_ca_system_score_gemma":0.0009450894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001981018,"about_ca_topic_score_gemma":0.003248391,"domain_scores_codex":[0.9995465,0.00005771913,0.00005661894,0.00009476094,0.00007689073,0.0001676139],"domain_scores_gemma":[0.9988207,0.000180863,0.0002387251,0.00020184,0.00008997125,0.0004678055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02136537,0.002879405,0.001417409,0.0002225442,0.0001964206,0.001823869,0.0001593255,0.000547357,0.9562018,0.000958464,0.001403375,0.01282469],"study_design_scores_gemma":[0.000600547,0.006792905,0.004940155,0.00003210349,0.0001338893,0.001058744,0.0002387724,0.001714577,0.9806963,0.0005331746,0.003202114,0.00005675195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943069,0.0007011146,0.001028491,0.0006105449,0.0003070849,0.00004211589,0.0007934814,0.0003291409,0.001881204],"genre_scores_gemma":[0.9921131,0.0007025785,0.0009089345,0.0001521821,0.00005286074,0.00009170418,0.0009339764,0.00007399073,0.004970761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004268804,"threshold_uncertainty_score":0.01428056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03287758777868271,"score_gpt":0.3065303490239811,"score_spread":0.2736527612452984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}