{"id":"W2577868635","doi":"10.1038/ncomms14003","title":"K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; University of Toronto; University Health Network; York University; Ontario Institute for Cancer Research","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Fonds National de la Recherche Luxembourg","keywords":"Ubiquitin ligase; KLF4; Ubiquitin; DNA ligase; Cell cycle; Ubiquitin-Protein Ligases; Cell growth; Cell biology; Cell cycle progression; Cell; Biology; Chemistry; Genetics; DNA; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001311722,0.0002425911,0.0001974339,0.000256577,0.0002229165,0.0004360188,0.0001573836,0.0001908263,0.001390821],"category_scores_gemma":[0.000132124,0.0001406788,0.0002195006,0.0001134439,0.0002184654,0.0002914676,0.0002814834,0.0002770939,0.0006109215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00043217,"about_ca_system_score_gemma":0.0001563707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003122965,"about_ca_topic_score_gemma":0.0004567881,"domain_scores_codex":[0.999871,0.00002290484,0.00001063048,0.00002997482,0.00001954273,0.00004593529],"domain_scores_gemma":[0.9998579,0.00001390362,0.00005460938,0.00002091319,0.00001811468,0.00003453864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002345346,0.0000199922,0.001220282,0.00002480885,0.000005581202,0.00007468719,0.00001052179,0.000114969,0.995732,0.0002163849,0.0000802002,0.002266026],"study_design_scores_gemma":[0.00001493195,0.0001031224,0.007689414,0.000005333333,0.000008453126,0.0002090811,0.00003176681,0.002088191,0.9874939,0.0001678552,0.002181798,0.000006124892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915732,0.001673192,0.004080977,0.00009793107,0.00002827085,0.00001288521,0.0003292973,0.000186799,0.002017521],"genre_scores_gemma":[0.9973155,0.000248441,0.0008310691,0.00001732048,0.000005302349,0.000005001736,0.0001608884,0.00001385944,0.001402586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001390821,"threshold_uncertainty_score":0.004652739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318704113032243,"score_gpt":0.3417277574052388,"score_spread":0.3285407162749163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}