{"id":"W2578216260","doi":"10.1182/blood.v118.21.986.986","title":"ERN1/IRE1 and XBP1 Are Dispensable for Myeloma Cell Survival but Are Required for the Anti-Myeloma Activity of Bortezomib","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"XBP1; Bortezomib; Unfolded protein response; Gene silencing; ATF6; Endoplasmic reticulum; Biology; RNA interference; Gene knockdown; Cancer research; Molecular biology; Small interfering RNA; Cell biology; Transfection; Cell culture; Multiple myeloma; Immunology; Gene; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001411395,0.0002438042,0.0002714754,0.0001432622,0.0001665209,0.0002935704,0.0001704608,0.000205133,0.001593559],"category_scores_gemma":[0.0001069599,0.0001867453,0.000185354,0.0001282669,0.0001472088,0.0001515255,0.0002039617,0.000512656,0.0005864087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002857562,"about_ca_system_score_gemma":0.0002205313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006034474,"about_ca_topic_score_gemma":0.001082895,"domain_scores_codex":[0.999856,0.00001772478,0.00001622529,0.00002860477,0.00005359662,0.00002778809],"domain_scores_gemma":[0.9998579,0.00002393506,0.00004751868,0.00001836078,0.0000124465,0.00003987565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008100948,0.000008990157,0.0001232029,0.00001090734,0.000002180959,0.00003072235,0.000003790157,0.00003400197,0.9992086,0.00002641591,0.00002888573,0.0004413447],"study_design_scores_gemma":[0.00002622679,0.000147702,0.01709854,0.000004476139,0.00001314057,0.0003878206,0.00002171517,0.001358142,0.9780467,0.00003296394,0.002857907,0.000004525224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945511,0.001718554,0.00136349,0.000101914,0.000021774,0.0000158514,0.0009744198,0.00007603593,0.001176853],"genre_scores_gemma":[0.9929762,0.0006029281,0.001394547,0.00006231861,0.000008182323,0.00002245165,0.00208079,0.0000312275,0.002821476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001593559,"threshold_uncertainty_score":0.00533098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06193309665663511,"score_gpt":0.2925165551521706,"score_spread":0.2305834584955355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}