{"id":"W2578409681","doi":"10.1002/cbic.201600708","title":"An Exceptionally Selective DNA Cooperatively Binding Two Ca<sup>2+</sup> Ions","year":2017,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; China Scholarship Council","keywords":"DNA; Chemistry; Ion; Biophysics; Combinatorial chemistry; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002016274,0.0002774275,0.000234023,0.00005687814,0.000762563,0.0001590998,0.0004795565,0.0002140884,0.00001471652],"category_scores_gemma":[0.0001813797,0.000257761,0.0001487758,0.00008447102,0.0002979727,0.00002160569,0.0001602178,0.0001641814,0.0000235862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004651865,"about_ca_system_score_gemma":0.0001059231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000280106,"about_ca_topic_score_gemma":0.00002984593,"domain_scores_codex":[0.9985649,0.00004647098,0.0002160826,0.0006588445,0.0001680309,0.0003456759],"domain_scores_gemma":[0.998467,0.000008862139,0.0001769062,0.0008860984,0.000306454,0.000154683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004331958,0.0001071005,0.0005921141,0.000004910514,0.00009287657,0.00000456613,0.00007504489,0.0000356446,0.9954551,0.00005883521,0.002310731,0.001219771],"study_design_scores_gemma":[0.0004385469,0.0001867945,0.0005392646,0.00002004985,0.0000408571,0.00002203113,0.0001545832,0.0005641541,0.9942576,0.00009061817,0.003313542,0.0003719414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942708,0.00005613561,0.001238645,0.0002594309,0.00003520732,0.0001514805,0.00007869743,0.00007094619,0.00383867],"genre_scores_gemma":[0.991915,0.00006279323,0.004808037,0.0002456666,0.0005133731,0.00002201376,0.0005649059,0.00003523413,0.001832992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003569392,"threshold_uncertainty_score":0.9999875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01499380150899542,"score_gpt":0.3130167551598885,"score_spread":0.2980229536508931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}