{"id":"W2578704408","doi":"10.1182/blood.v126.23.3439.3439","title":"Natural Killer Cells Activated By Oncolytic Reovirus Enhance Cetuximab Mediated Antibody Dependent Cellular Cytotoxicity in an in Vitro and In Vivo Model of Colorectal Cancer","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Antibody-dependent cell-mediated cytotoxicity; Cetuximab; Cytotoxicity; Oncolytic virus; Interleukin 12; Immune system; Cytotoxic T cell; Cancer research; Natural killer cell; Antibody; Interleukin 21; Biology; Chemistry; Immunology; In vitro; Monoclonal antibody; T cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002772678,0.0005065939,0.0004432935,0.0002904523,0.0001075575,0.0002691271,0.0002340454,0.0004090588,0.001449193],"category_scores_gemma":[0.0001346588,0.0001973929,0.00035097,0.0001428867,0.0001728542,0.0002192164,0.0001630825,0.001229482,0.0004000186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003158965,"about_ca_system_score_gemma":0.000232203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001246664,"about_ca_topic_score_gemma":0.001547282,"domain_scores_codex":[0.9997022,0.00006382016,0.00002642417,0.00004891488,0.00007291314,0.00008569697],"domain_scores_gemma":[0.9998797,0.00003037345,0.0000247096,0.00001949437,0.00001877042,0.00002703981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000267872,0.0002402875,0.00007229886,0.0000610315,0.000006175672,0.00004676851,0.00002363878,0.0001512973,0.9981728,0.00004935962,0.00004950571,0.0008590379],"study_design_scores_gemma":[0.00006176152,0.002750891,0.001463303,0.000008420888,0.00002043896,0.0001880415,0.00002502273,0.001577299,0.9928145,0.00002529896,0.001060489,0.000004417428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913573,0.001956828,0.003541239,0.0001324261,0.0001341613,0.000155051,0.0004628877,0.0001327651,0.002127345],"genre_scores_gemma":[0.9903123,0.0008764844,0.003468729,0.00005725002,0.00002112014,0.0001420633,0.0006038768,0.00001762704,0.004500492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001449193,"threshold_uncertainty_score":0.004848063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351801123874271,"score_gpt":0.2968146190110096,"score_spread":0.2832966077722669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}