{"id":"W2578807992","doi":"10.1182/blood.v110.11.4150.4150","title":"Decreased Expression of the Histone Methyltransferase SUV39H1 in AML Cells Reactivates Hypermethylated Tumor Suppressor p15INK4B in the Absence of Promoter Demethylation.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Decitabine; Trichostatin A; Methyltransferase; DNA methylation; Molecular biology; Methylation; Chromatin immunoprecipitation; Cancer research; Biology; Histone methyltransferase; EZH2; DNA methyltransferase; Epigenetics; DNA demethylation; Chemistry; Histone; Histone deacetylase; Promoter; Gene expression; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001441321,0.0004195493,0.0004317286,0.0002607986,0.0001848966,0.0003099192,0.0002655268,0.0003001968,0.00203858],"category_scores_gemma":[0.0001255063,0.0002141296,0.0002829212,0.0002230286,0.0002681802,0.0001579669,0.0002292251,0.0007303158,0.0005434769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005198593,"about_ca_system_score_gemma":0.0002267033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001205451,"about_ca_topic_score_gemma":0.001421056,"domain_scores_codex":[0.9997231,0.00003140516,0.00003355032,0.00006181433,0.00008796396,0.00006204124],"domain_scores_gemma":[0.9998496,0.00002572858,0.00003860303,0.00003228195,0.00001030651,0.00004357783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000568386,0.00002011226,0.0001350438,0.00001075677,0.000004279645,0.00001993712,0.000006470395,0.00003140317,0.999131,0.00003809752,0.00002111209,0.0005250486],"study_design_scores_gemma":[0.00000754314,0.0001022737,0.00160271,8.479876e-7,0.000003692952,0.00004043303,0.000005588137,0.0003150395,0.997366,0.00001037941,0.0005447175,9.400558e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949986,0.001012681,0.001725795,0.0001001768,0.00005853166,0.00004768185,0.0007925616,0.0001863055,0.001077735],"genre_scores_gemma":[0.9948961,0.0002899552,0.001447687,0.00003169941,0.000007120477,0.00005337252,0.0007924256,0.00002488438,0.00245668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00203858,"threshold_uncertainty_score":0.006819665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009190101039867464,"score_gpt":0.2533464193212188,"score_spread":0.2441563182813513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}