{"id":"W2579077000","doi":"10.1182/blood.v114.22.3580.3580","title":"PD-L1 Immuno-Gene Therapy Under Cell Fate Control: Persistence of Cellular Delivery Vehicle and Transgene Expression.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"","keywords":"Biology; Jurkat cells; Genetic enhancement; CD19; Gene delivery; T cell; Cell biology; Transgene; Viral vector; Transfection; Cell therapy; Ex vivo; Molecular biology; Flow cytometry; Immune system; In vivo; Gene; Stem cell; Immunology; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003987595,0.0003475709,0.0002080642,0.0002112543,0.0001948423,0.000543537,0.0002588908,0.0006260691,0.002400282],"category_scores_gemma":[0.0001715444,0.0001930531,0.000237801,0.0001485375,0.0003127837,0.0003815584,0.0002580172,0.000853686,0.000810397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006378408,"about_ca_system_score_gemma":0.0004267002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000416147,"about_ca_topic_score_gemma":0.0004260431,"domain_scores_codex":[0.9997684,0.00003732894,0.00001399304,0.00005642682,0.00006534043,0.00005857794],"domain_scores_gemma":[0.9999208,0.0000188439,0.00002309019,0.000009500301,0.00001373379,0.00001396492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009977324,0.00008185197,0.00009535712,0.00004019943,0.000003437861,0.00003974641,0.0000243142,0.0001152854,0.9912464,0.0009415092,0.0002647658,0.007047437],"study_design_scores_gemma":[0.00002415943,0.0002604537,0.0003564155,0.000006089092,0.00001260696,0.0001289771,0.00000961441,0.001045956,0.9916047,0.000101249,0.006445827,0.000003907956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8744112,0.00887513,0.09075622,0.001283887,0.0004213333,0.0005385822,0.0005862783,0.0006137796,0.02251359],"genre_scores_gemma":[0.956206,0.002135399,0.01710759,0.0002069594,0.00004464625,0.0002076815,0.0005104302,0.00007651434,0.02350485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002400282,"threshold_uncertainty_score":0.008029759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02661883014036972,"score_gpt":0.2510072339640696,"score_spread":0.2243884038236999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}