{"id":"W2579122244","doi":"10.1074/jbc.m116.750380","title":"Differential Contribution of Transmembrane Domains IV, V, VI, and VII to Human Angiotensin II Type 1 Receptor Homomer Formation","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Transmembrane domain; Angiotensin II; Receptor; G protein-coupled receptor; Transmembrane protein; Biophysics; Chemistry; Biology; Signal transduction; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001191834,0.0001258781,0.0001433707,0.00009562432,0.0000911728,0.0002706654,0.0001154641,0.0001804597,0.0007365685],"category_scores_gemma":[0.0001979985,0.00007297616,0.0002162585,0.00007274465,0.0001067203,0.0001114009,0.0001012898,0.0002903202,0.0002431774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000200762,"about_ca_system_score_gemma":0.0001271325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004907965,"about_ca_topic_score_gemma":0.0003547632,"domain_scores_codex":[0.999867,0.00003066663,0.000008792834,0.00001935533,0.00003313429,0.00004105919],"domain_scores_gemma":[0.9999034,0.00002653343,0.00002542273,0.000006014761,0.00001285553,0.00002575019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002319002,0.00001134315,0.0006127561,0.00002626063,0.000008370476,0.00008538798,0.00002266651,0.000130255,0.9975121,0.0001215396,0.00003492002,0.00120265],"study_design_scores_gemma":[0.00001749601,0.0002650494,0.02073678,0.00001272929,0.00003941253,0.0006173503,0.00009058534,0.002772273,0.9729705,0.0001234095,0.002343593,0.00001073563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976569,0.0009263159,0.0007924409,0.00004060541,0.000008923967,0.00000530543,0.00007173958,0.000009514257,0.0004882005],"genre_scores_gemma":[0.9977875,0.0008113782,0.0005907876,0.00005900693,0.000004649681,0.00000611743,0.0002064868,0.000008143768,0.0005259925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007365685,"threshold_uncertainty_score":0.002464056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01701334320011413,"score_gpt":0.2615873813284917,"score_spread":0.2445740381283776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}