{"id":"W2579151267","doi":"","title":"The Case for Selection at CCR5-Δ32","year":2005,"lang":"en","type":"article","venue":"NSUWorks (Nova Southeastern University)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University; Damon Runyon Cancer Research Foundation; Cancer Research Institute","keywords":"Biology; Locus (genetics); Genetics; Allele; Linkage disequilibrium; Chemokine receptor CCR5; Evolutionary biology; Selection (genetic algorithm); Genetic variation; Balancing selection; Chemokine receptor; Gene; Haplotype; Receptor; Chemokine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001272592,0.0001262016,0.0001139947,0.0001047097,0.0009526754,0.00002172956,0.0001759162,0.0001576577,0.0002951418],"category_scores_gemma":[0.00001872554,0.00009638161,0.000107449,0.0001692762,0.0001447123,0.00007184326,0.00009662071,0.0001812863,0.002182398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001494092,"about_ca_system_score_gemma":0.0000473658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008140015,"about_ca_topic_score_gemma":0.002690358,"domain_scores_codex":[0.9991041,0.0001076294,0.00009702209,0.0002352885,0.00002627899,0.0004296128],"domain_scores_gemma":[0.9994336,0.0001951503,0.00005141159,0.0001960408,0.00008022699,0.00004350553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01455978,0.001741746,0.05900347,0.00009430715,0.004638127,0.002530217,0.007177958,0.000627451,0.03004057,0.02354183,0.04060291,0.8154416],"study_design_scores_gemma":[0.003552662,0.0002657284,0.0004616473,0.00001272286,0.00008645425,0.0009670703,0.001889264,0.0001090036,0.002658973,0.00002903892,0.9897849,0.0001825315],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804788,0.0008632292,0.003746941,0.001924001,0.0003973386,0.0007733637,0.000239919,0.0001454174,0.01143097],"genre_scores_gemma":[0.8788924,0.00002247622,0.00008060615,0.00002516286,0.00005410312,0.000002854166,0.00005058073,0.00001118915,0.1208606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.949182,"threshold_uncertainty_score":0.9985945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02112927041930463,"score_gpt":0.2393013342014096,"score_spread":0.218172063782105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}