{"id":"W2579550050","doi":"10.1080/10242422.2016.1266617","title":"Optimization of simultaneous production of tyrosinase and laccase by<i>Neurospora crassa</i>","year":2017,"lang":"en","type":"article","venue":"Biocatalysis and Biotransformation","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Ministry of Science Research and Technology; National Institute for Genetic Engineering and Biotechnology","keywords":"Laccase; Neurospora crassa; Tyrosinase; Chemistry; Crassa; Biochemistry; Enzyme; Catechol oxidase; Food science; Polyphenol oxidase; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001326859,0.00007458363,0.0001015184,0.00003349917,0.0001132772,0.00002711765,0.00005113516,0.00007172552,0.000002103637],"category_scores_gemma":[0.00005029228,0.0000665182,0.00002665069,0.00003165143,0.0001033651,0.00002563359,0.00001615784,0.00001838173,1.689746e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002473764,"about_ca_system_score_gemma":0.000008052838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000401413,"about_ca_topic_score_gemma":0.000008609809,"domain_scores_codex":[0.9994953,0.00001789854,0.0002036034,0.0001431171,0.00008253762,0.0000575249],"domain_scores_gemma":[0.9995027,0.000004283027,0.0002083077,0.0001803081,0.00007626929,0.00002810595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000810514,0.00004501485,0.001749969,0.00009509412,0.00001950631,2.031121e-7,0.00009531798,0.0003907732,0.9895031,0.00001728074,0.0001071034,0.007895522],"study_design_scores_gemma":[0.0003489818,0.000147842,0.001182184,0.0000156126,0.00004611396,0.000006293178,0.00008448471,0.003965761,0.9939127,0.000005449901,0.0002055002,0.00007905287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912321,0.0003205658,0.008015671,0.0001076073,0.00005887404,0.0001398263,0.00004285486,0.00000310739,0.00007941143],"genre_scores_gemma":[0.9972876,0.00158563,0.0005739675,0.00001310378,0.0000248537,0.00000283554,0.0004590497,0.000005032384,0.00004792236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007816469,"threshold_uncertainty_score":0.2712533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005958450793200485,"score_gpt":0.2330816577654352,"score_spread":0.2271232069722347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}