{"id":"W2579583537","doi":"10.1083/jcb.201608128","title":"VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis","year":2017,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":280,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; SickKids Foundation; University of Toronto; University Health Network; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Peroxisome; Endoplasmic reticulum; Cell biology; Biogenesis; Organelle; Membrane contact site; Lipid droplet; Catabolism; Lipid metabolism; Biology; Plasmalogen; Membrane protein; Biochemistry; Chemistry; Receptor; Integral membrane protein; Metabolism; Phospholipid; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001243635,0.000281105,0.000177358,0.000200388,0.0004263792,0.0004263757,0.0002851936,0.000429979,0.002769684],"category_scores_gemma":[0.000157124,0.0001464077,0.0003638548,0.0001638114,0.0002540781,0.0004121927,0.0006572109,0.0006170601,0.001246772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006251131,"about_ca_system_score_gemma":0.0002440549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001053147,"about_ca_topic_score_gemma":0.001465259,"domain_scores_codex":[0.9998447,0.00002464264,0.00001287553,0.00003331475,0.00004944654,0.0000350687],"domain_scores_gemma":[0.9999093,0.00001260387,0.00002118745,0.00001241145,0.00001275574,0.00003173415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001010703,0.00001136156,0.0005795258,0.00004033557,0.000007392062,0.0001158185,0.00001625005,0.00007591071,0.9972798,0.0004416688,0.00007985628,0.001251058],"study_design_scores_gemma":[0.00001812662,0.00006109638,0.01104959,0.00001135301,0.00001576173,0.0006794782,0.0001165136,0.002411619,0.9750576,0.0001812694,0.01039024,0.000007313753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883246,0.001999304,0.007065928,0.0002332962,0.00006505271,0.00001412872,0.0003590642,0.0001023686,0.001836333],"genre_scores_gemma":[0.9927528,0.0003387692,0.002330819,0.0000676726,0.000006878731,0.00001074142,0.0006630882,0.00002021897,0.00380909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002769684,"threshold_uncertainty_score":0.009265482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01231675724757741,"score_gpt":0.266032632162726,"score_spread":0.2537158749151486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}