{"id":"W2579583537","doi":"10.1083/jcb.201608128","title":"VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis","year":2017,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":280,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; SickKids Foundation; University of Toronto; University Health Network; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Peroxisome; Endoplasmic reticulum; Cell biology; Biogenesis; Organelle; Membrane contact site; Lipid droplet; Catabolism; Lipid metabolism; Biology; Plasmalogen; Membrane protein; Biochemistry; Chemistry; Receptor; Integral membrane protein; Metabolism; Phospholipid; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007752808,0.0001741183,0.0002441209,0.00004311027,0.0004214181,0.00005767357,0.0005865152,0.0001632017,0.00001270178],"category_scores_gemma":[0.0003491331,0.00008686644,0.00008090962,0.00002669902,0.00037539,0.00001111233,0.0002562547,0.0001892752,0.000002587578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000124616,"about_ca_system_score_gemma":0.00005356765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008304237,"about_ca_topic_score_gemma":0.00001548222,"domain_scores_codex":[0.9990636,0.0001478611,0.0002472125,0.0001852871,0.00006701318,0.0002889917],"domain_scores_gemma":[0.9988623,0.0000931574,0.0003363615,0.00042698,0.0001708457,0.0001104024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004199432,0.00002275515,0.001279325,0.00001125362,0.00008331169,4.814749e-7,0.0002506291,0.000004449495,0.9877308,0.00002825137,0.001688269,0.008480533],"study_design_scores_gemma":[0.0009418337,0.001207785,0.001943707,0.00001636544,0.00005650244,0.0001137086,0.000382103,0.0000103625,0.7289674,0.000257024,0.2659312,0.0001720475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897658,0.003269618,0.0006573899,0.005464605,0.000362869,0.0002483927,0.00002840359,0.000002652288,0.0002002675],"genre_scores_gemma":[0.9935884,0.003912774,0.0004932504,0.0008820787,0.0005984507,0.00001124384,0.000003569109,0.00002256765,0.0004876109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2642429,"threshold_uncertainty_score":0.354231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01231675724757741,"score_gpt":0.266032632162726,"score_spread":0.2537158749151486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}