{"id":"W2579645842","doi":"10.1021/acschembio.6b01002","title":"An Engineered Allele of <i>afsQ1</i> Facilitates the Discovery and Investigation of Cryptic Natural Products","year":2017,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Toronto","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada; Government of Canada","keywords":"Biology; Streptomyces; Computational biology; Drug discovery; Gene; Antibiotics; Multiple drug resistance; Antimicrobial; Regulator; Antibiotic resistance; Genetics; Microbiology; Bacteria; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002569545,0.0003760283,0.000243305,0.0002706479,0.000141034,0.0003621926,0.0003121533,0.0003321721,0.002162478],"category_scores_gemma":[0.0002030636,0.000128888,0.000287318,0.0002202621,0.0003289369,0.0001982855,0.0003950114,0.0008132535,0.0008120171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002363692,"about_ca_system_score_gemma":0.0002822116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004629673,"about_ca_topic_score_gemma":0.0006122648,"domain_scores_codex":[0.9998036,0.00003157087,0.00002548979,0.00004108557,0.00006406056,0.0000342177],"domain_scores_gemma":[0.9997517,0.00004513769,0.00009187448,0.00003710207,0.00001555867,0.00005855088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003489557,0.00001810572,0.0001152913,0.0000115733,0.000001694343,0.00004198133,0.00000639666,0.000056863,0.9983634,0.0001806865,0.00004968015,0.001119489],"study_design_scores_gemma":[0.00001725451,0.0001678028,0.002365968,0.000006244485,0.000009432336,0.0005528136,0.00002733987,0.002105492,0.987864,0.0001130715,0.006761219,0.000009360182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9449244,0.0003321556,0.04689705,0.0004893059,0.00009949076,0.0001238242,0.001981402,0.0007988915,0.004353511],"genre_scores_gemma":[0.9660573,0.0003551054,0.0267023,0.0001153023,0.0000281237,0.00006654923,0.001779745,0.0002485937,0.004647068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002162478,"threshold_uncertainty_score":0.007234216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455024975964042,"score_gpt":0.2493290553756818,"score_spread":0.2347788056160414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}