{"id":"W2579757892","doi":"10.1182/blood.v120.21.414.414","title":"Results From the Dose Escalation Phase of a Randomized Phase 1–2 First-in-Human (FIH) Study of SGI-110, a Novel Low Volume Stable Subcutaneous (SQ) Second Generation Hypomethylating Agent (HMA) in Patients with Relapsed/Refractory MDS and AML","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Decitabine; Tolerability; Medicine; Hypomethylating agent; Regimen; Neutropenia; Phases of clinical research; Pharmacodynamics; Pharmacokinetics; Internal medicine; Nausea; Adverse effect; Febrile neutropenia; Pharmacology; Oncology; Clinical trial; Toxicity; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001891848,0.0002365655,0.0008597035,0.0002796564,0.00009708026,0.00002234789,0.0001203112,0.000124437,0.00006933585],"category_scores_gemma":[0.001047611,0.0001656875,0.00006463273,0.0004202877,0.0001325579,0.0002610717,0.00008073201,0.0004122184,0.000001425529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001760904,"about_ca_system_score_gemma":0.0001240553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001882171,"about_ca_topic_score_gemma":0.001261223,"domain_scores_codex":[0.9970664,0.0004150379,0.001079419,0.0003812728,0.0006804357,0.000377394],"domain_scores_gemma":[0.9977568,0.0008012167,0.0005654701,0.0005065417,0.0002270752,0.0001428672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2999483,0.09579261,0.3322416,0.0003213981,0.001306986,0.0001216771,0.05326417,0.0003553582,0.2105293,0.00001141035,0.0002588296,0.005848419],"study_design_scores_gemma":[0.8841583,0.004963175,0.09629239,0.0002285798,0.000470397,0.000007445924,0.001034886,0.006274869,0.00631641,0.000004712334,0.00003468401,0.0002141453],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959869,0.0002964585,0.00005620985,0.00003875637,0.00004720838,0.003232935,0.0002242804,0.00001428613,0.0001029816],"genre_scores_gemma":[0.998633,0.0000175465,0.0005745162,0.0000200642,0.0001158762,0.0000875691,0.0004014825,0.00003850607,0.0001114279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.58421,"threshold_uncertainty_score":0.6756542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02489592603019248,"score_gpt":0.2882658855887609,"score_spread":0.2633699595585685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}