{"id":"W2579757892","doi":"10.1182/blood.v120.21.414.414","title":"Results From the Dose Escalation Phase of a Randomized Phase 1–2 First-in-Human (FIH) Study of SGI-110, a Novel Low Volume Stable Subcutaneous (SQ) Second Generation Hypomethylating Agent (HMA) in Patients with Relapsed/Refractory MDS and AML","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Decitabine; Tolerability; Medicine; Hypomethylating agent; Regimen; Neutropenia; Phases of clinical research; Pharmacodynamics; Pharmacokinetics; Internal medicine; Nausea; Adverse effect; Febrile neutropenia; Pharmacology; Oncology; Clinical trial; Toxicity; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004396768,0.001649259,0.002147137,0.0004115983,0.0004127399,0.0006300575,0.0007155696,0.001140734,0.003611817],"category_scores_gemma":[0.002484015,0.0006418671,0.001102465,0.0003741611,0.001147486,0.0008111171,0.0004597713,0.003408531,0.0006393032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008233112,"about_ca_system_score_gemma":0.001320295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005182346,"about_ca_topic_score_gemma":0.0007848907,"domain_scores_codex":[0.9983517,0.001128823,0.00009061133,0.0001385274,0.0001129959,0.0001774982],"domain_scores_gemma":[0.9981849,0.0005819659,0.0003622345,0.0002283443,0.0001016421,0.0005409864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7509171,0.1102356,0.01029865,0.0004488292,0.000954321,0.0002133862,0.0004293761,0.003763043,0.04528672,0.0002482268,0.002828734,0.07437604],"study_design_scores_gemma":[0.5396954,0.4329213,0.0170953,0.00001443807,0.0003699191,0.000161976,0.0000320078,0.001130998,0.006638362,0.0001777505,0.001735096,0.00002748181],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932184,0.0004767406,0.0006932832,0.0002826942,0.00004109006,0.003498253,0.0009230927,0.00005770953,0.0008088136],"genre_scores_gemma":[0.9829969,0.0005163178,0.004472708,0.0007706162,0.0001519804,0.005569502,0.003333443,0.00004261033,0.002145989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004396768,"threshold_uncertainty_score":0.02325261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02489592603019248,"score_gpt":0.2882658855887609,"score_spread":0.2633699595585685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}