{"id":"W2579867384","doi":"10.1073/pnas.1615141114","title":"Recognition of protein-linked glycans as a determinant of peptidase activity","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University; National Research Council Canada; University of Victoria","funders":"Canadian Institutes of Health Research; National Center for Research Resources; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Glycan; Glycoprotein; Glycosylation; Posttranslational modification; Biochemistry; Peptide; Chemistry; Cleavage (geology); Protein–protein interaction; N-linked glycosylation; Biology; Cell biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000232731,0.000208452,0.0001729336,0.0001492485,0.0001030696,0.0006905793,0.0001912412,0.0002701426,0.0004162256],"category_scores_gemma":[0.0003217898,0.0001046096,0.0001540386,0.0001822124,0.0003255752,0.0002335189,0.0001533322,0.0005294636,0.0002237997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002521685,"about_ca_system_score_gemma":0.0001525298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005138916,"about_ca_topic_score_gemma":0.0004225624,"domain_scores_codex":[0.9998428,0.00003573449,0.00001072148,0.00002676134,0.00005128903,0.00003268971],"domain_scores_gemma":[0.99984,0.0000531098,0.00003833807,0.00001271003,0.00001912345,0.00003667102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004652053,0.000006740486,0.001116188,0.0000125139,0.000003367594,0.0000516553,0.00001542508,0.00006244329,0.9976783,0.0001317649,0.00001490588,0.0008602513],"study_design_scores_gemma":[0.000004325208,0.0001073397,0.02079496,0.000004238826,0.000009856488,0.0004367302,0.00007542978,0.00145312,0.9760075,0.0001816749,0.0009181607,0.000006636596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994067,0.0009278547,0.003364577,0.00009877334,0.000009576266,0.000008545972,0.0001031454,0.00001846511,0.001402123],"genre_scores_gemma":[0.9972754,0.0003026421,0.001838299,0.00002495426,0.000003235673,0.000003308324,0.0001082325,0.000004082048,0.000439901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006905793,"threshold_uncertainty_score":0.001829624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06579931434087795,"score_gpt":0.3579243557337131,"score_spread":0.2921250413928352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}