{"id":"W2580398445","doi":"10.1158/1535-7163.mct-16-0644","title":"Targeted Treatment of Metastatic Breast Cancer by PLK1 siRNA Delivered by an Antioxidant Nanoparticle Platform","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; University of Texas at El Paso; University of Toronto; Oregon Health and Science University","keywords":"Metastatic breast cancer; Cancer research; Breast cancer; Cancer; Kinome; Metastasis; Triple-negative breast cancer; Cancer cell; Cytotoxicity; Gene knockdown; In vivo; PLK1; Medicine; Chemistry; Biology; Kinase; In vitro; Internal medicine; Apoptosis; Cell cycle; Cell biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001845617,0.0003637924,0.0004862094,0.00004649712,0.0003544937,0.0001899755,0.0006130724,0.00007946011,0.0004943666],"category_scores_gemma":[0.000006139421,0.0003137944,0.0001304566,0.0001158376,0.0003321279,0.0004870622,0.00006797174,0.00006827072,0.00002998708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003428829,"about_ca_system_score_gemma":0.0002270269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004457847,"about_ca_topic_score_gemma":0.0002685832,"domain_scores_codex":[0.997714,0.0001171927,0.0004749675,0.0005348817,0.0005224624,0.0006364739],"domain_scores_gemma":[0.9979938,0.00003074912,0.0004627704,0.001075893,0.0002126906,0.0002240805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003222739,0.0007711308,0.001307462,0.00002126131,0.0002012093,0.00002869506,0.0004009417,0.0005035467,0.9812016,0.0000424037,0.0001446602,0.01505483],"study_design_scores_gemma":[0.002503363,0.0004303258,0.0008339255,0.00003741484,0.0003514128,0.000007473526,0.00008753411,0.003083084,0.9905905,0.00009319535,0.001605597,0.0003762014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881957,0.007464886,0.0006394222,0.0006742774,0.0003270793,0.0004438619,0.002160595,0.00007298002,0.00002122942],"genre_scores_gemma":[0.9976352,0.0009435519,0.0005307682,0.00052452,0.00003544983,0.000140966,0.00002522697,0.00006834971,0.00009599051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01467863,"threshold_uncertainty_score":0.9999314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02817487700869737,"score_gpt":0.2928454558962161,"score_spread":0.2646705788875187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}