{"id":"W2580398445","doi":"10.1158/1535-7163.mct-16-0644","title":"Targeted Treatment of Metastatic Breast Cancer by PLK1 siRNA Delivered by an Antioxidant Nanoparticle Platform","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; University of Texas at El Paso; University of Toronto; Oregon Health and Science University","keywords":"Metastatic breast cancer; Cancer research; Breast cancer; Cancer; Kinome; Metastasis; Triple-negative breast cancer; Cancer cell; Cytotoxicity; Gene knockdown; In vivo; PLK1; Medicine; Chemistry; Biology; Kinase; In vitro; Internal medicine; Apoptosis; Cell cycle; Cell biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007091524,0.0003185606,0.0001839904,0.0001448609,0.00009440706,0.0001607046,0.0001449116,0.0002578119,0.0005562395],"category_scores_gemma":[0.00004556681,0.0001030551,0.000188115,0.00005395127,0.0001143317,0.0001445731,0.0001407575,0.0002376815,0.0002071419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000259598,"about_ca_system_score_gemma":0.0001567064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003735557,"about_ca_topic_score_gemma":0.0004469178,"domain_scores_codex":[0.9999577,0.000004457109,0.000002944248,0.00001437934,0.00001121731,0.00000927158],"domain_scores_gemma":[0.9999769,0.000002980932,0.000007885651,0.000001750889,0.000005008321,0.000005543626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003114926,0.0000104099,0.00003594087,0.00003093773,0.000003248168,0.00002011627,0.000005062916,0.0001060875,0.9984862,0.00003929686,0.0000361026,0.001195459],"study_design_scores_gemma":[0.00001024086,0.0002015145,0.0003431151,0.000002639684,0.00001304552,0.0000882932,0.000004317608,0.001239844,0.996741,0.00001614266,0.00133714,0.00000273105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981128,0.00277873,0.01366012,0.0001828482,0.00005033852,0.00006292382,0.0001905955,0.0002358155,0.001710661],"genre_scores_gemma":[0.9912189,0.0008650928,0.005573556,0.00006516262,0.0000105665,0.00005550283,0.0001266944,0.00001329847,0.002071237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005562395,"threshold_uncertainty_score":0.001883507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02817487700869737,"score_gpt":0.2928454558962161,"score_spread":0.2646705788875187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}