{"id":"W2580453358","doi":"10.3389/fimmu.2017.00038","title":"Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds","year":2017,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Natural Science Foundation of China","keywords":"Antibody-dependent cell-mediated cytotoxicity; Antibody; Epitope; Monoclonal antibody; Fragment crystallizable region; Antigen; Cytotoxicity; Effector; Fc receptor; Chemistry; Humanized antibody; Cancer research; Immunology; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003048289,0.000444399,0.002277812,0.0007408499,0.0001727477,0.00005031717,0.0003581799,0.0005270329,0.000007168077],"category_scores_gemma":[0.0001239783,0.0003516908,0.0003060848,0.0001409761,0.0003222652,0.00006342207,0.0002061976,0.0004243284,0.00001064155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001844995,"about_ca_system_score_gemma":0.0003714251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000031327,"about_ca_topic_score_gemma":0.000006601606,"domain_scores_codex":[0.998144,0.00003964801,0.0005414393,0.0005032402,0.0001379919,0.0006337278],"domain_scores_gemma":[0.9990301,0.0002094058,0.000196642,0.0004334969,0.000071099,0.00005924911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001371918,0.00003566561,0.0002606804,0.0122519,0.0009582906,0.00003302491,0.00004772068,1.096871e-7,0.00003625181,0.001337747,0.0008829414,0.9840184],"study_design_scores_gemma":[0.0006687627,0.0001699846,0.0006782417,0.007654062,0.0002326904,0.0002662362,0.00002749604,0.00006679707,0.000009847181,0.0001099315,0.9897711,0.0003448976],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008420597,0.9925349,0.004103125,0.0002689723,0.001613844,0.00108259,0.00006424147,0.00003354277,0.0002145324],"genre_scores_gemma":[0.00002087486,0.9797838,0.01715983,0.00003302211,0.0002295019,0.0001804971,0.0001615139,0.00007201963,0.002358924],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9888881,"threshold_uncertainty_score":0.9998935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1303844867159075,"score_gpt":0.3886493921081733,"score_spread":0.2582649053922659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}