{"id":"W2580493818","doi":"10.3324/haematol.2016.154377","title":"Safety and efficacy of abexinostat, a pan-histone deacetylase inhibitor, in non-Hodgkin lymphoma and chronic lymphocytic leukemia: results of a phase II study","year":2017,"lang":"en","type":"article","venue":"Haematologica","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Pharmacyclics; Servier","keywords":"Medicine; Follicular lymphoma; Adverse effect; Internal medicine; Neutropenia; Lymphoma; Histone deacetylase inhibitor; Gastroenterology; Chronic lymphocytic leukemia; Oncology; Pharmacology; Histone deacetylase; Immunology; Leukemia; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002547465,0.0007131331,0.001914932,0.0002958527,0.000291337,0.0006731225,0.0005650058,0.0008558359,0.00123037],"category_scores_gemma":[0.0009424571,0.0003438413,0.001087101,0.000329538,0.0005987735,0.0006779459,0.0001957691,0.001725591,0.0003596062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000701283,"about_ca_system_score_gemma":0.0009177317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006444148,"about_ca_topic_score_gemma":0.001575892,"domain_scores_codex":[0.9993979,0.0003202061,0.00004664771,0.00007127396,0.00007045031,0.0000935783],"domain_scores_gemma":[0.9990747,0.0002078794,0.0002123736,0.00008728979,0.00008299555,0.0003347012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4731798,0.09472377,0.03424184,0.001615168,0.002650513,0.001027436,0.0006190496,0.003091438,0.1137685,0.0003420971,0.004982467,0.269758],"study_design_scores_gemma":[0.2536263,0.6544256,0.07257574,0.0000789296,0.001028325,0.0009349428,0.0001296079,0.00171482,0.009667411,0.0002472241,0.005526973,0.0000440758],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930218,0.003319148,0.0005619421,0.000243442,0.00004275375,0.001080351,0.0005835371,0.00004881011,0.001098158],"genre_scores_gemma":[0.9921718,0.002631993,0.0007898168,0.00065889,0.00009318357,0.0008774889,0.001632437,0.00001962841,0.00112471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002547465,"threshold_uncertainty_score":0.0134725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595690113616621,"score_gpt":0.3266580733588823,"score_spread":0.3107011722227161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}