{"id":"W2580495053","doi":"10.1182/blood.v114.22.1046.1046","title":"Modulation of Histone H3K4 and H3K27 Methylation Levels Via Pharmacological Inhibition of LSD1 and Degradation of the EZH2-Containing Polycomb Repressive Complex 2 Stimulates ATRA-Mediated Differentiation of AML Cells.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"EZH2; Cellular differentiation; Retinoic acid; Cancer research; Tretinoin; Biology; Acute promyelocytic leukemia; Haematopoiesis; Retinoid; Retinoic acid receptor; Gene silencing; Stem cell; Cell biology; Epigenetics; Cell culture; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000112031,0.0002285707,0.0002337036,0.0001536872,0.0001521192,0.0002357617,0.0001858735,0.000184955,0.004837824],"category_scores_gemma":[0.00007150985,0.0001557161,0.000322101,0.0001277342,0.000206364,0.0001364271,0.0002389359,0.0005546887,0.0009054051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002473295,"about_ca_system_score_gemma":0.0002156272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005779435,"about_ca_topic_score_gemma":0.001374258,"domain_scores_codex":[0.9999211,0.00000838725,0.000006532508,0.00001612389,0.00001594513,0.00003187301],"domain_scores_gemma":[0.9999568,0.000005861812,0.00001023745,0.000006241093,0.000003084778,0.00001771043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005443685,0.00008655858,0.0001707786,0.0000487338,0.0000112735,0.00003602525,0.00001407287,0.00007673354,0.9961588,0.00009236819,0.0002176842,0.002542465],"study_design_scores_gemma":[0.0001139759,0.0006735855,0.004669224,0.000004247358,0.00002041993,0.0001374293,0.00002491961,0.001009687,0.9900684,0.00006243329,0.003209126,0.000006534151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901328,0.00250985,0.001495837,0.0002116705,0.00006868922,0.0000555909,0.001005288,0.0002645589,0.00425571],"genre_scores_gemma":[0.9934933,0.0006353161,0.0007863994,0.00004834405,0.00001083791,0.00004118556,0.0008470404,0.00002243795,0.004115151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004837824,"threshold_uncertainty_score":0.01618409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03744741966734066,"score_gpt":0.3270388937491313,"score_spread":0.2895914740817906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}