{"id":"W2580791746","doi":"10.1158/1055-9965.epi-16-0728","title":"Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium","year":2017,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Human Genome Research Institute; National Cancer Institute; Cancer Research UK; National Institutes of Health; National Institute for Health and Care Research; Wellcome Trust","keywords":"Oncology; Breast cancer; Internal medicine; Prostate cancer; Prostate; Single-nucleotide polymorphism; Ovarian cancer; Epigenetics; Medicine; Biology; Cancer; Gene; Genotype; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00338511,0.0006426384,0.0008436716,0.001052492,0.0007089904,0.001231842,0.001116394,0.0007658847,0.004259925],"category_scores_gemma":[0.008995234,0.0003204971,0.002643415,0.002160606,0.0003782017,0.0004029194,0.001480509,0.0006913923,0.0002278581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005267208,"about_ca_system_score_gemma":0.0008229222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02619639,"about_ca_topic_score_gemma":0.02887464,"domain_scores_codex":[0.9967027,0.00187484,0.0001544162,0.0007526645,0.0002678908,0.0002473482],"domain_scores_gemma":[0.9964225,0.001420398,0.000739712,0.0007286857,0.0003914328,0.0002974055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008214916,0.00008784339,0.9129436,0.000733029,0.0545234,0.0007387779,0.0002408076,0.001180837,0.001465564,0.001477194,0.007691498,0.0107024],"study_design_scores_gemma":[0.0020989,0.0007634011,0.8855926,0.0007523786,0.08578923,0.001712451,0.0005913578,0.004330241,0.001450414,0.00409819,0.01271356,0.0001071963],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9664072,0.009852352,0.005655529,0.001009449,0.0002744402,0.0001419622,0.01180588,0.0001231784,0.004730098],"genre_scores_gemma":[0.9930828,0.0008140423,0.001106039,0.0002380973,0.00004682113,0.00008762669,0.003390346,0.00003870157,0.001195536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02619639,"threshold_uncertainty_score":0.05208784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1151373472226458,"score_gpt":0.3907362319516463,"score_spread":0.2755988847290005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}