{"id":"W2580809488","doi":"10.2337/db16-0636","title":"Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis","year":2017,"lang":"en","type":"article","venue":"Diabetes","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Department of Medicine, University of Toronto; National Institute of Diabetes and Digestive and Kidney Diseases; Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; University of Toronto; Canadian Association of Gastroenterology; Canadian Diabetes Association","keywords":"Exocytosis; Syntaxin; Cell biology; Granule (geology); Secretion; Insulin; Biology; Lipid bilayer fusion; SNARE complex; Syntaxin 3; Internal medicine; Endocrinology; Chemistry; Membrane; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001549348,0.000501766,0.0002728202,0.0001830808,0.0001587998,0.0004344833,0.0001858488,0.0002834663,0.0004047841],"category_scores_gemma":[0.00008494111,0.0001282598,0.0002982486,0.0001241845,0.0001957499,0.0004629161,0.0003359945,0.0002846826,0.0001199876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002460517,"about_ca_system_score_gemma":0.0001773099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000173345,"about_ca_topic_score_gemma":0.0002550254,"domain_scores_codex":[0.9998842,0.00001758601,0.00001633479,0.00003268231,0.0000295528,0.00001961874],"domain_scores_gemma":[0.9999483,0.000004764279,0.00002091957,0.000006054679,0.000006807938,0.00001330154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008711999,0.000005962895,0.0004230093,0.00003019202,0.000007136126,0.000146066,0.000007885432,0.00007769553,0.9985167,0.0001515115,0.00001745933,0.000529201],"study_design_scores_gemma":[0.00002389939,0.0002767043,0.01054931,0.00001266324,0.00004177969,0.001337079,0.00005785055,0.002183487,0.9818252,0.0001952929,0.003483896,0.00001287896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865479,0.004201387,0.007229921,0.0001337169,0.00003259767,0.0000210655,0.0002559662,0.00008305639,0.001494411],"genre_scores_gemma":[0.9937479,0.002065618,0.002526674,0.00005266763,0.0000105345,0.00001347419,0.0003067431,0.00001419573,0.001262067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000501766,"threshold_uncertainty_score":0.001785219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01199207735571382,"score_gpt":0.2418207172537587,"score_spread":0.2298286398980449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}