{"id":"W2580961998","doi":"10.1073/pnas.1611602114","title":"Direct measurement of sequence-dependent transition path times and conformational diffusion in DNA duplex formation","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Institute for Nanotechnology; University of Alberta","funders":"","keywords":"Folding (DSP implementation); Base pair; Duplex (building); Chemical physics; Sequence (biology); Molecular dynamics; Diffusion; Crystallography; Chemistry; Helix (gastropod); Nucleic acid; Path (computing); DNA; Transition (genetics); Transition state; Biophysics; Physics; Computational chemistry; Thermodynamics; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003885279,0.0002137061,0.0001500692,0.000455238,0.0002292744,0.0003580448,0.0002464362,0.0004027902,0.001163263],"category_scores_gemma":[0.002276402,0.0002237525,0.0001188396,0.0002922509,0.0005566109,0.0007422168,0.0002731875,0.00100837,0.0002209244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000495314,"about_ca_system_score_gemma":0.0002629348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000628527,"about_ca_topic_score_gemma":0.0006210163,"domain_scores_codex":[0.9997697,0.00003875331,0.000008183334,0.00009389243,0.00006498282,0.0000244701],"domain_scores_gemma":[0.9989067,0.0006203512,0.0001868404,0.0000534407,0.000102803,0.0001298357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001448327,0.00003185723,0.001394001,0.00003256127,0.000004751499,0.00001738994,0.00008237975,0.0005651376,0.9938308,0.000651931,0.00004051315,0.003203824],"study_design_scores_gemma":[0.00002314911,0.0002969295,0.01098006,0.00001188176,0.00001578202,0.0001600872,0.00006883815,0.01762161,0.9690939,0.0007013584,0.0009963945,0.0000298743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803194,0.0004861231,0.01786732,0.00005731336,0.00002579979,0.00002876927,0.0001805792,0.00009234708,0.000942229],"genre_scores_gemma":[0.9916565,0.0002157275,0.007184388,0.00002467689,0.000007699667,0.00003689698,0.0001122843,0.00002028644,0.0007415096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001163263,"threshold_uncertainty_score":0.003891528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03460563263838942,"score_gpt":0.2778078386192553,"score_spread":0.2432022059808659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}