{"id":"W2580985654","doi":"","title":"The Hedgehog signalling pathway and its role in cancer","year":2001,"lang":"en","type":"dissertation","venue":"Figshare","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"British Medical Association; University Hospitals of Leicester NHS Trust; McMaster University","keywords":"Hedgehog signaling pathway; Hedgehog; Signalling; Cancer; Smoothened; Signalling pathways; Biology; Cancer research; Computational biology; Cell biology; Signal transduction; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006503211,0.000244888,0.0001856977,0.00003937838,0.0001782427,0.00005158623,0.0002168725,0.0003195753,0.001477067],"category_scores_gemma":[0.0004766135,0.0001994227,0.00006642262,0.00009259023,0.000005257795,0.000002363699,0.0000720685,0.0002188676,0.00006229848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002102091,"about_ca_system_score_gemma":0.0001672524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001499584,"about_ca_topic_score_gemma":0.001674674,"domain_scores_codex":[0.9989297,0.000042277,0.0002138409,0.0003928454,0.0001297221,0.0002916479],"domain_scores_gemma":[0.9994673,0.00004418769,0.0001269482,0.0001634646,0.0001466549,0.00005145564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004949978,0.0001658931,0.000506564,0.002267273,0.0006589271,0.0001370322,0.003377206,0.0006758292,0.7347171,0.00003809732,0.151467,0.1054941],"study_design_scores_gemma":[0.0004245334,0.0001171698,0.001986198,0.003173664,0.0000225399,0.000004900444,0.001084337,0.0001572606,0.3304667,0.00005595503,0.6618015,0.0007052969],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4733668,0.4111111,3.302167e-7,0.000106077,0.0005365789,0.001288436,0.09542239,0.00005839856,0.01810985],"genre_scores_gemma":[0.7104014,0.004922686,0.00000724677,0.0001673757,0.001040147,0.001576191,0.2521905,0.0001402506,0.02955416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5103346,"threshold_uncertainty_score":0.9994357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0275764295596425,"score_gpt":0.286447665740937,"score_spread":0.2588712361812945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}