{"id":"W2581094758","doi":"10.1182/blood.v106.11.438.438","title":"Leukemic Stem Cells of Chronic Phase CML Patients Possess Uniquely Elevated BCR-ABL Kinase Activity and Acquire Spontaneous BCR-ABL Kinase Domain Mutations at a High Frequency.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; BC Cancer Agency","funders":"","keywords":"CD38; Tyrosine kinase; Imatinib mesylate; Biology; Cancer research; Stem cell; ABL; Molecular biology; breakpoint cluster region; Haematopoiesis; Progenitor cell; CD117; CD34; Imatinib; Myeloid leukemia; Cell biology; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007317148,0.0002361896,0.0001815288,0.0003357833,0.0002132254,0.0001975932,0.00005938395,0.0001658097,0.003071971],"category_scores_gemma":[0.0001486507,0.0001133237,0.00009797917,0.0002600458,0.0001787639,0.00009381333,0.0001601622,0.0003540082,0.0006164881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001177923,"about_ca_system_score_gemma":0.0001142265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002186322,"about_ca_topic_score_gemma":0.0003726713,"domain_scores_codex":[0.9999398,0.000008103958,0.000005927398,0.0000145949,0.00001943349,0.00001209711],"domain_scores_gemma":[0.9998978,0.0000199334,0.00002417418,0.00001291783,0.00001170186,0.00003342957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001833413,0.00003214267,0.008144868,0.00003640353,0.000006155152,0.0002994954,0.0001099322,0.00002634399,0.9865617,0.0001055612,0.0001089082,0.004385061],"study_design_scores_gemma":[0.0001464141,0.002442241,0.3301885,0.0000278381,0.00005543097,0.01389151,0.0004241337,0.0007549329,0.6329947,0.0005831461,0.0184762,0.00001508155],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973907,0.0003600607,0.0007764356,0.00004441966,0.000006644937,0.00003931901,0.0004491132,0.00002775158,0.0009055067],"genre_scores_gemma":[0.9959401,0.0002729087,0.001282293,0.00004217308,0.00001420145,0.0000654429,0.00127936,0.000009235747,0.001094334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003071971,"threshold_uncertainty_score":0.01027673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00918812710597172,"score_gpt":0.2464831289828766,"score_spread":0.2372950018769049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}