{"id":"W2581142439","doi":"10.1021/acs.analchem.6b04573","title":"Revealing and Resolving the Restrained Enzymatic Cleavage of DNA Self-Assembled Monolayers on Gold: Electrochemical Quantitation and ESI-MS Confirmation","year":2017,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Ministry of Education of the People's Republic of China; Scientific Research Foundation for Returned Scholars of Ministry of Education; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Chemistry; DNA; Self-assembled monolayer; Cleavage (geology); Electrochemistry; Monolayer; Hydrolysis; Combinatorial chemistry; Redox; Steric effects; Enzymatic hydrolysis; Electrode; Stereochemistry; Organic chemistry; Biochemistry; Physical chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004018881,0.000514583,0.0002875507,0.0003994038,0.0001600953,0.0002831187,0.0004498243,0.0006203277,0.0004933317],"category_scores_gemma":[0.0007760437,0.0002838871,0.000221244,0.0002437004,0.0002809297,0.0002949965,0.0002932174,0.0005942616,0.0003169312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001987788,"about_ca_system_score_gemma":0.0001653619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002548431,"about_ca_topic_score_gemma":0.0004816017,"domain_scores_codex":[0.9996507,0.00005159519,0.00002552321,0.00007500601,0.0001604423,0.00003676804],"domain_scores_gemma":[0.9996234,0.0001324993,0.00006895042,0.00004172887,0.00009762435,0.000035769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007862955,0.000004724416,0.000117513,0.00001812125,0.000003889309,0.00002507381,0.00001282858,0.00002591893,0.9990376,0.00002062181,0.000007074018,0.0007187714],"study_design_scores_gemma":[0.000001214193,0.00003259585,0.001024154,0.000001780344,0.000005211264,0.00009128428,0.00001197019,0.0007905929,0.99777,0.00003245292,0.000236361,0.000002543384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9570922,0.00206751,0.03911258,0.0001411072,0.00005362148,0.00005706583,0.000262918,0.0001935933,0.001019303],"genre_scores_gemma":[0.9523251,0.001364899,0.04400179,0.000126152,0.00002038179,0.00007554216,0.0002742462,0.00002914302,0.001782735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006203277,"threshold_uncertainty_score":0.002125382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163571770993966,"score_gpt":0.286527625624223,"score_spread":0.2748919079142834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}