{"id":"W2581179619","doi":"10.1038/ng.3781","title":"Systematic analysis of telomere length and somatic alterations in 31 cancer types","year":2017,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":627,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Cancer Prevention and Research Institute of Texas; University of Texas MD Anderson Cancer Center; Broad Institute; McGill University; National Cancer Institute; National Institutes of Health","keywords":"Telomere; Telomerase; Biology; ATRX; Death-associated protein 6; Telomerase reverse transcriptase; Cancer; Somatic cell; Cancer research; DNA methylation; Genetics; Molecular biology; Mutation; DNA; Gene; Gene expression; Transcription factor; Nuclear protein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005912604,0.000179604,0.0004749236,0.002660112,0.00042296,0.0004253044,0.0002179742,0.0002375737,0.00131098],"category_scores_gemma":[0.001174794,0.0001906628,0.0005633107,0.00208128,0.0002474281,0.0001485912,0.000551443,0.0002585201,0.0002778667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002672797,"about_ca_system_score_gemma":0.0003903068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001321547,"about_ca_topic_score_gemma":0.003567328,"domain_scores_codex":[0.9994942,0.00006074796,0.00007418088,0.000164191,0.0001260246,0.00008052166],"domain_scores_gemma":[0.9983214,0.0005185521,0.0004541828,0.0003206287,0.0002424351,0.0001428854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00290165,0.00006354036,0.6334845,0.0004763355,0.001039998,0.0007286119,0.0002862092,0.0004334748,0.3149969,0.000172368,0.0004888029,0.04492754],"study_design_scores_gemma":[0.00002480798,0.000244899,0.9738421,0.00002547294,0.0006413654,0.001894857,0.0001103533,0.0002674522,0.01978225,0.0001030839,0.003050553,0.00001282529],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942095,0.001804667,0.0005309073,0.00001667123,0.000005132019,0.00001830396,0.002965869,0.00002464852,0.0004243366],"genre_scores_gemma":[0.9940461,0.001003476,0.0008150628,0.00002822411,0.000007056828,0.00002032201,0.003611876,0.00001922886,0.000448625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002660112,"threshold_uncertainty_score":0.00438565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01453095944649037,"score_gpt":0.3177384194143332,"score_spread":0.3032074599678428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}