{"id":"W2581181917","doi":"10.1182/blood.v108.11.3375.3375","title":"Mobilization Studies in Immunodeficient Mice Support a Role of Complement in Modulating the Trafficking of Hematopoietic Stem Cells (HSC) - A Pivotal Role of C3 Cleavage Fragments in Retention and C5 Fragments in Mobilization/Egress of HSC.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Mobilization; Complement system; Haematopoiesis; Immune system; Chemokine; Alternative complement pathway; Severe combined immunodeficiency; Cell biology; Classical complement pathway; Stem cell; Homing (biology); Complement component 5; Immunology; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000494577,0.001182492,0.0003791974,0.001396266,0.0004253381,0.0004053583,0.0004921978,0.0007149343,0.004357814],"category_scores_gemma":[0.0002224295,0.0002516518,0.0005415879,0.0003455817,0.0007695063,0.0004656694,0.0006020846,0.001361032,0.0008310811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005600954,"about_ca_system_score_gemma":0.0003111072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006225114,"about_ca_topic_score_gemma":0.000705989,"domain_scores_codex":[0.9996808,0.00006335061,0.00004292902,0.00007298643,0.00007595166,0.00006408116],"domain_scores_gemma":[0.9995143,0.00008926282,0.0001904039,0.00006409555,0.00002953223,0.0001123119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001115446,0.00004100014,0.0001181319,0.00005790489,0.000005413855,0.00007690211,0.00001867177,0.00002467576,0.9985587,0.0003090287,0.00002358387,0.0006545975],"study_design_scores_gemma":[0.00002885103,0.0004721671,0.002364505,0.00002640882,0.00002362465,0.0004427228,0.00002132265,0.0002558963,0.9945356,0.0001643778,0.001657848,0.000006847467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978298,0.00364279,0.01114411,0.0003452905,0.00007342383,0.0001862841,0.001791153,0.0004335934,0.004085295],"genre_scores_gemma":[0.9816173,0.002828686,0.008257926,0.0001884271,0.0000379585,0.0002292507,0.001610013,0.0001044248,0.005126128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004357814,"threshold_uncertainty_score":0.01457834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354731890379234,"score_gpt":0.2391962070002152,"score_spread":0.2256488880964229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}