{"id":"W2581199101","doi":"10.1158/1538-8514.pi3k14-b51","title":"Abstract B51: The tyrphostin, NT157, suppresses insulin receptor substrates and augments therapeutic response of prostate cancer","year":2015,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver General Hospital","funders":"","keywords":"LNCaP; Prostate cancer; IRS1; Cancer research; Protein kinase B; Androgen receptor; PI3K/AKT/mTOR pathway; MAPK/ERK pathway; Insulin-like growth factor 1 receptor; Endocrinology; Internal medicine; Signal transduction; Insulin receptor; Growth factor; Biology; Cancer; Receptor; Medicine; Insulin; Insulin resistance; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009275098,0.0003664947,0.0003148825,0.0002082414,0.0001110406,0.0001934973,0.0002442347,0.000281031,0.003546603],"category_scores_gemma":[0.00007667861,0.00009673405,0.0002007958,0.0001287668,0.0001510483,0.000142061,0.00009925963,0.0006770135,0.0006711445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002259168,"about_ca_system_score_gemma":0.0002851243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008093501,"about_ca_topic_score_gemma":0.00126834,"domain_scores_codex":[0.999949,0.000007188598,0.000004656262,0.000008206091,0.00001882293,0.00001208381],"domain_scores_gemma":[0.9999504,0.000005530542,0.00001045371,0.000005396912,0.000006194256,0.00002195937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001164404,0.0007549805,0.0002292409,0.0000826028,0.00001831892,0.0000836888,0.00001071905,0.0002973546,0.9882455,0.0001159429,0.0005014002,0.008495971],"study_design_scores_gemma":[0.0005259652,0.01374269,0.007671609,0.00002517951,0.00005920365,0.0005952849,0.00002458705,0.001583527,0.9689471,0.00004314224,0.0067702,0.00001144737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935947,0.001580717,0.0007162017,0.0001452687,0.0000862993,0.00008417357,0.0006695928,0.0001081656,0.003014753],"genre_scores_gemma":[0.9924035,0.001040298,0.0008471335,0.00009614758,0.00002154125,0.00005407415,0.001210302,0.00001852002,0.004308531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003546603,"threshold_uncertainty_score":0.01186454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03238721274005957,"score_gpt":0.3056067351111244,"score_spread":0.2732195223710648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}