{"id":"W2581252948","doi":"10.18632/oncotarget.14850","title":"Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance","year":2017,"lang":"en","type":"article","venue":"Oncotarget","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Genome British Columbia; University of British Columbia","funders":"University of British Columbia","keywords":"Prostate cancer; Reprogramming; Cancer research; Cancer stem cell; Transdifferentiation; Biology; Stem cell; Androgen deprivation therapy; Cancer; Cell biology; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001131653,0.0001099386,0.0001128315,0.00001668883,0.0001508641,0.00003914197,0.0001333546,0.0000776129,0.00001892866],"category_scores_gemma":[0.000009740831,0.00009971428,0.00003830422,0.00001971083,0.00009455926,0.00001108308,0.00002591302,0.00002611615,0.000001067799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001352736,"about_ca_system_score_gemma":0.00006066288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007057092,"about_ca_topic_score_gemma":0.000123453,"domain_scores_codex":[0.9993246,0.00002354575,0.0001507196,0.000260693,0.0001018452,0.0001386153],"domain_scores_gemma":[0.999455,0.000002663538,0.0001551586,0.0002841377,0.00006254627,0.00004050334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002658362,0.00002919198,0.05059702,0.000009723382,0.00003735207,6.171007e-7,0.0002273846,0.000001129789,0.938679,0.00000812498,0.000255011,0.009889589],"study_design_scores_gemma":[0.0008191467,0.00007590332,0.1366381,0.00001516202,0.000002065876,5.553716e-7,0.00002977783,0.00000258236,0.8013877,0.0000220426,0.06089923,0.0001076979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973201,0.001728402,0.00001905849,0.0001777865,0.000133111,0.0002388091,0.00002113646,0.000008225717,0.0003533747],"genre_scores_gemma":[0.9956298,0.001670132,0.001598322,0.00005340434,0.00005301271,0.00002915863,0.00003065134,0.00001722384,0.0009182923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1372913,"threshold_uncertainty_score":0.406623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02595104678282211,"score_gpt":0.2835230995971961,"score_spread":0.257572052814374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}