{"id":"W2581343726","doi":"10.1182/blood.v116.21.204.204","title":"Stromal Cell-Derived Secreted Factors Contribute to the Innate Imatinib Resistance of Leukemia Stem Cells In a Genetically Defined Murine Model of Chronic Myeloid Leukemia Blast Crisis","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Royal University Hospital; University of Saskatchewan","funders":"","keywords":"Myeloid leukemia; Cancer research; Dasatinib; Biology; Stem cell; Imatinib; Bone marrow; Leukemia; Haematopoiesis; Immunology; CD117; Nilotinib; Imatinib mesylate; CD34; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002923601,0.0006628569,0.0003116273,0.000635088,0.0002244123,0.0004025042,0.0003342327,0.0006900155,0.002102745],"category_scores_gemma":[0.0001014538,0.0002551105,0.0003698203,0.0001987464,0.0004376808,0.0002888223,0.0002871964,0.00140694,0.0006901057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003871447,"about_ca_system_score_gemma":0.0002645744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003867449,"about_ca_topic_score_gemma":0.000653928,"domain_scores_codex":[0.9996631,0.00007216704,0.00004159619,0.00004948445,0.00009980264,0.0000739067],"domain_scores_gemma":[0.9997717,0.00002171179,0.00007365717,0.00002737465,0.0000149751,0.0000906493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002412386,0.000154619,0.0001440125,0.00003106983,0.000003984136,0.0000737372,0.00002044734,0.0001104351,0.9983184,0.0002607307,0.00004868162,0.0005926462],"study_design_scores_gemma":[0.0001991893,0.002381786,0.004232537,0.00002809149,0.00002865418,0.0005851394,0.0000771321,0.003057078,0.9844671,0.0001639203,0.0047691,0.00001022682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936504,0.0008408586,0.002385816,0.0002279739,0.00004597447,0.0001980384,0.001010287,0.0001096893,0.001531019],"genre_scores_gemma":[0.9915584,0.0005920868,0.002948077,0.00009319075,0.0000193522,0.0002515318,0.001016976,0.00003050487,0.003489784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002102745,"threshold_uncertainty_score":0.007034361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101819885872355,"score_gpt":0.226776076302328,"score_spread":0.2157578774436044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}