{"id":"W2581357176","doi":"10.1182/blood.v126.23.371.371","title":"Spatiotemporal Analysis of Intraclonal Heterogeneity in Multiple Myeloma: Unravelling the Impact of Treatment and the Propagating Capacity of Subclones Using Whole Exome Sequencing","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Exome sequencing; Somatic evolution in cancer; Multiple myeloma; Exome; Biology; Plasma cell leukemia; Genetic heterogeneity; CDKN2A; Cancer research; Neuroblastoma RAS viral oncogene homolog; Bone marrow; Mutation; Pathology; Cancer; Genetics; Immunology; Medicine; Phenotype; Gene; KRAS","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003913573,0.0001395392,0.0002511418,0.0004847601,0.0001623993,0.000486557,0.000175139,0.0002562599,0.0007121005],"category_scores_gemma":[0.0006211007,0.0001150619,0.0002444791,0.0005928071,0.000167752,0.0002314621,0.0003406741,0.0002832456,0.0001557202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001909644,"about_ca_system_score_gemma":0.000110633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000789667,"about_ca_topic_score_gemma":0.001261323,"domain_scores_codex":[0.999774,0.00004257861,0.00002217591,0.00007495169,0.00005780913,0.0000284596],"domain_scores_gemma":[0.999731,0.0000983554,0.00006059743,0.00004472433,0.00004695646,0.00001837635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007033539,0.00006912508,0.2088532,0.0002055834,0.0001916194,0.0003790765,0.0002466258,0.003710487,0.7395749,0.0002423941,0.0003165651,0.04550708],"study_design_scores_gemma":[0.00002616464,0.0003598641,0.8588904,0.00003362064,0.0002022549,0.001359881,0.0003616628,0.01491859,0.1195407,0.0006550451,0.00362848,0.00002332356],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928606,0.0008769837,0.004795392,0.00006217115,0.000004725333,0.00001984388,0.0008973926,0.00002773718,0.0004551225],"genre_scores_gemma":[0.9948225,0.0002784649,0.003598199,0.00005672448,0.000005983547,0.00002283975,0.0009033331,0.00001715799,0.0002948385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000789667,"threshold_uncertainty_score":0.002382219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1211170023696429,"score_gpt":0.3399996376657051,"score_spread":0.2188826352960622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}