{"id":"W2581402891","doi":"10.1039/c6ra28443d","title":"Hydroxybenzylidene-indolinones, c-di-AMP synthase inhibitors, have antibacterial and anti-biofilm activities and also re-sensitize resistant bacteria to methicillin and vancomycin","year":2017,"lang":"en","type":"article","venue":"RSC Advances","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada)","funders":"Division of Chemistry; Purdue University; National Science Foundation","keywords":"Biofilm; Microbiology; Vancomycin; Bacteria; Chemistry; Biology; Staphylococcus aureus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003501422,0.0003765789,0.0005045899,0.00007032452,0.0006380629,0.0004207147,0.0001382164,0.0002749033,0.000008665774],"category_scores_gemma":[0.0003296196,0.0003486785,0.00005681354,0.00002915457,0.0004141609,0.00007502863,0.0004100245,0.0001429469,0.000001582478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001191983,"about_ca_system_score_gemma":0.00004435312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001603333,"about_ca_topic_score_gemma":0.001275579,"domain_scores_codex":[0.9981941,0.0001159093,0.0003433906,0.0007711204,0.0001424028,0.0004331014],"domain_scores_gemma":[0.9987929,0.00007236876,0.00027518,0.0005809105,0.00006604261,0.0002125748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000556266,0.00002151897,0.001894286,0.00006965087,0.00004196451,0.00002185229,0.0001378561,0.000001042326,0.990002,0.00003271532,0.00009031861,0.007130483],"study_design_scores_gemma":[0.0008394325,0.0002888802,0.01963588,0.0002168626,0.00004720705,0.00005817011,0.0002877516,0.000008255352,0.9320964,0.00005561453,0.04589519,0.0005703442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958687,0.002131942,0.00003489323,0.0005635654,0.0006988869,0.0002777836,0.0002284318,0.00002266765,0.0001731314],"genre_scores_gemma":[0.991557,0.00304407,0.004078706,0.0001728955,0.0008665287,0.000005630509,0.00005355866,0.00004270927,0.000178923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05790564,"threshold_uncertainty_score":0.9998965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01476029308145925,"score_gpt":0.2744038744403267,"score_spread":0.2596435813588674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}