{"id":"W2581402891","doi":"10.1039/c6ra28443d","title":"Hydroxybenzylidene-indolinones, c-di-AMP synthase inhibitors, have antibacterial and anti-biofilm activities and also re-sensitize resistant bacteria to methicillin and vancomycin","year":2017,"lang":"en","type":"article","venue":"RSC Advances","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada)","funders":"Division of Chemistry; Purdue University; National Science Foundation","keywords":"Biofilm; Microbiology; Vancomycin; Bacteria; Chemistry; Biology; Staphylococcus aureus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001990381,0.0003947013,0.0002661475,0.0003290354,0.0001247367,0.0002485543,0.0004049925,0.0002856917,0.001534911],"category_scores_gemma":[0.0001818967,0.0001435708,0.0002025124,0.0001997624,0.0002093568,0.0002439275,0.0002520701,0.0009237614,0.000910043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003127252,"about_ca_system_score_gemma":0.0002541683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004892761,"about_ca_topic_score_gemma":0.001649762,"domain_scores_codex":[0.9998636,0.00002471698,0.000009999964,0.0000203273,0.00005582609,0.00002548612],"domain_scores_gemma":[0.9998119,0.00003561391,0.00006961589,0.00001342023,0.00002976005,0.00003968895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002407502,0.0001189883,0.0001824631,0.0003821981,0.00001393846,0.00008711581,0.00002512407,0.0002688679,0.9602979,0.0009616216,0.0006961374,0.03672498],"study_design_scores_gemma":[0.0001084577,0.001063454,0.002429883,0.00004960254,0.00003675561,0.0006114979,0.00002975101,0.0007451643,0.9365846,0.0003369221,0.05797078,0.00003313067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5761653,0.3295281,0.02810832,0.002211853,0.001057732,0.000310858,0.001403255,0.0008459106,0.06036869],"genre_scores_gemma":[0.9032251,0.06819186,0.01125589,0.0005899843,0.0001251829,0.000101125,0.0009125869,0.00005143761,0.01554691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001534911,"threshold_uncertainty_score":0.005134761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01476029308145925,"score_gpt":0.2744038744403267,"score_spread":0.2596435813588674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}