{"id":"W2581462115","doi":"10.1172/jci.insight.89580","title":"Transient stimulation expands superior antitumor T cells for adoptive therapy","year":2017,"lang":"en","type":"article","venue":"JCI Insight","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Japan Society for the Promotion of Science; National Institutes of Health; University of Toronto; National Cancer Institute; Princess Margaret Cancer Foundation","keywords":"CD28; Adoptive cell transfer; Cell therapy; CD8; Immunotherapy; Cytotoxic T cell; T cell; Immunology; Cancer research; Stimulation; Medicine; Chimeric antigen receptor; Antigen; Biology; Cell biology; Immune system; In vitro; Stem cell; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001959173,0.0001648326,0.0003099738,0.0001082646,0.0003347686,0.0001082721,0.0001805511,0.0001033665,0.001446011],"category_scores_gemma":[0.00003764269,0.0001292163,0.0001828781,0.00005846834,0.0001315773,0.0001834251,0.00001689945,0.0001585615,0.00004267165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007324111,"about_ca_system_score_gemma":0.0001116786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003666461,"about_ca_topic_score_gemma":0.00001178094,"domain_scores_codex":[0.9987999,0.00002694091,0.0002077004,0.000311004,0.0003416291,0.0003127771],"domain_scores_gemma":[0.9988146,0.00008572152,0.00007172567,0.0006636666,0.0002189969,0.0001453048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002583175,0.0003650539,0.002139205,0.00006530011,0.0001102743,0.00004286111,0.003333898,0.00001793094,0.9390758,0.0001653983,0.001398071,0.05070308],"study_design_scores_gemma":[0.00972475,0.001953602,0.0301582,0.00008861364,0.00004468934,0.00001247736,0.0001317519,0.001878327,0.6151514,0.0001142028,0.340481,0.0002609306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775912,0.0004407524,0.0009669389,0.0007975318,0.0004465705,0.001791685,0.00002716643,0.00005803391,0.0178801],"genre_scores_gemma":[0.9879745,0.0006669233,0.0006734956,0.0002498566,0.0004770869,0.000111667,0.00003279287,0.00004707578,0.009766659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.339083,"threshold_uncertainty_score":0.9994668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07534149144604835,"score_gpt":0.3615606458141226,"score_spread":0.2862191543680743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}