{"id":"W2581468657","doi":"10.1038/ncomms14015","title":"Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institutes of Health; Azrieli Foundation; Israel Science Foundation","keywords":"Telomere; Subtelomere; Biology; RNA; DNA; Hybrid; DNA damage; Genetics; RNase P; Chromosome; Genome; Cell biology; Molecular biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021967,0.0003102524,0.0002976794,0.0007575112,0.0002878991,0.0002963219,0.0001305901,0.0004238632,0.001860387],"category_scores_gemma":[0.0002115884,0.0001562885,0.0002711626,0.0003000612,0.0002210829,0.0001651317,0.0002534396,0.0004491641,0.0003735505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001324729,"about_ca_system_score_gemma":0.0001096607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007775478,"about_ca_topic_score_gemma":0.0009333378,"domain_scores_codex":[0.9998674,0.00001175488,0.00001657939,0.00004256668,0.0000391461,0.00002257708],"domain_scores_gemma":[0.9998056,0.00002800083,0.00006873817,0.00002766379,0.00001361028,0.00005639164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009262031,0.000008951964,0.003501615,0.00002293113,0.00001414471,0.000634297,0.00008405659,0.000041439,0.9935763,0.00007010904,0.00005487766,0.00189867],"study_design_scores_gemma":[0.00002683041,0.0005155891,0.2215428,0.00002509281,0.00008484902,0.01581409,0.0003715643,0.001026919,0.754486,0.0003440839,0.005732118,0.0000301263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955361,0.001232844,0.001875516,0.00005411793,0.00001309298,0.00001123519,0.0003767951,0.0001006724,0.0007997582],"genre_scores_gemma":[0.9970421,0.0003848409,0.001104678,0.00003665112,0.000007709609,0.00001556321,0.0005262986,0.00002000919,0.0008620548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001860387,"threshold_uncertainty_score":0.006223619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02748605388135199,"score_gpt":0.3210429004604177,"score_spread":0.2935568465790657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}