{"id":"W2581610696","doi":"10.1182/blood.v116.21.4181.4181","title":"The WD40-Repeats of Ahi-1 Oncogene Critical for Protein Interaction Between Ahi-1 and BCR-ABL Modulates Imatinib-Induced Apoptosis In BCR-ABL-Transduced Cells","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Cancer research; Fusion protein; Biology; SH3 domain; Progenitor cell; ABL; breakpoint cluster region; Tyrosine kinase; Philadelphia chromosome; Myeloid leukemia; Stem cell; K562 cells; Haematopoiesis; Leukemia; Cell biology; Signal transduction; Immunology; Receptor; Chromosomal translocation; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001687853,0.0002439542,0.000217968,0.0001593556,0.0001843302,0.0002387576,0.0002355691,0.000233784,0.001771228],"category_scores_gemma":[0.00009631424,0.0001096458,0.0001787474,0.0001356154,0.0002063329,0.000154507,0.0001956286,0.0004911026,0.0004682437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002795641,"about_ca_system_score_gemma":0.0001275659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002894364,"about_ca_topic_score_gemma":0.0004082879,"domain_scores_codex":[0.9997898,0.00005162254,0.00002293093,0.00002518383,0.00005709835,0.00005340822],"domain_scores_gemma":[0.9999079,0.00002289242,0.00002089334,0.000009750049,0.000008175462,0.00003046163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001017584,0.00004976489,0.00008470511,0.0000174101,0.000003404058,0.00002966594,0.000008063988,0.00003127732,0.9992827,0.00007472248,0.00002402256,0.0002926084],"study_design_scores_gemma":[0.00004195616,0.0005952116,0.005867292,0.000009627001,0.00001399902,0.000251029,0.00004002202,0.001527229,0.9891708,0.00006331012,0.002415673,0.000003705248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967795,0.0009887827,0.0007672184,0.00006861133,0.00002313415,0.00003604656,0.0002797377,0.00002624034,0.00103067],"genre_scores_gemma":[0.9966581,0.0003725938,0.0006778569,0.00003046588,0.000006574799,0.00003589625,0.0006683234,0.000006704955,0.001543634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001771228,"threshold_uncertainty_score":0.005925417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02092562375732564,"score_gpt":0.3038845966690858,"score_spread":0.2829589729117601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}