{"id":"W2581634238","doi":"","title":"HDAC inhibitors alter retinal degeneration phenotypes and induce autophagy in Xenopus laevis models of retinal degeneration.","year":2016,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Retinal degeneration; Xenopus; Degeneration (medical); Autophagy; Retinal; Phenotype; Retinal regeneration; Biology; Cell biology; Neuroscience; Medicine; Ophthalmology; Genetics; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002456729,0.0005576409,0.0003292403,0.0009664453,0.0003297687,0.0003618589,0.0003191369,0.0004447599,0.001961763],"category_scores_gemma":[0.00008951103,0.0002762353,0.0005264668,0.0003221726,0.0003931288,0.0003698189,0.0001704341,0.0009321883,0.0004193326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007951838,"about_ca_system_score_gemma":0.0003800887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00269445,"about_ca_topic_score_gemma":0.007781188,"domain_scores_codex":[0.9997975,0.00003462302,0.00002776951,0.00003438738,0.0000498952,0.00005577408],"domain_scores_gemma":[0.9998477,0.00001685634,0.00006511364,0.0000162428,0.00001454598,0.00003956422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004204504,0.0001160345,0.0001729101,0.00005990341,0.00002241544,0.00005647701,0.00001932337,0.00008805895,0.9970236,0.0002150949,0.0002066799,0.0015989],"study_design_scores_gemma":[0.00008436327,0.000646807,0.00298603,0.00001425055,0.00004022316,0.0001338964,0.00003975799,0.0004135177,0.9936548,0.00006616332,0.001913499,0.000006709091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787275,0.007494987,0.002687177,0.0006383975,0.0001995686,0.0001323607,0.002373428,0.0005207948,0.007225808],"genre_scores_gemma":[0.9799514,0.004715779,0.00277786,0.0001393784,0.00002485661,0.0001260188,0.001097749,0.00007671375,0.01109018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00269445,"threshold_uncertainty_score":0.006562769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.031618227394257,"score_gpt":0.3237388476569807,"score_spread":0.2921206202627237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}