{"id":"W2581873141","doi":"10.1182/blood.v110.11.2299.2299","title":"Genetic Disruption of the SH3 and SAM Domains of HACS1 Enhances Adaptive Immunity.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Biology; Bone marrow; Immunology; B cell; Population; Immune system; Antigen; Molecular biology; B-1 cell; Spleen; T cell; Antibody; Antigen-presenting cell; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001681739,0.000664013,0.0002137387,0.0005427519,0.000205533,0.0002992681,0.0003539899,0.0004946921,0.003069878],"category_scores_gemma":[0.00009688038,0.0002423793,0.0003915051,0.0002013792,0.000529266,0.0001864093,0.0003186429,0.0009022037,0.0009066034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004421683,"about_ca_system_score_gemma":0.0001811104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007013237,"about_ca_topic_score_gemma":0.000934833,"domain_scores_codex":[0.9997683,0.00002909624,0.00002630139,0.00004143653,0.00006348673,0.00007133365],"domain_scores_gemma":[0.9996368,0.00005369142,0.0001356905,0.00002358181,0.00002082991,0.000129405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001079701,0.00001581438,0.0001207918,0.00002139972,0.000003457077,0.00003988971,0.000005598749,0.00005646921,0.9991693,0.00006543806,0.00003720102,0.0003567157],"study_design_scores_gemma":[0.00003957769,0.000275146,0.006749673,0.00001104764,0.00002243197,0.0003760248,0.00003657295,0.001593387,0.9877205,0.00005308818,0.003115104,0.000007313684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957443,0.0006036793,0.001451313,0.0001213687,0.00004550869,0.00002980662,0.0009486327,0.0001252549,0.0009302924],"genre_scores_gemma":[0.9942948,0.00032512,0.0009506641,0.00005470417,0.00001802042,0.00003741042,0.0009357327,0.00004663931,0.003336785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003069878,"threshold_uncertainty_score":0.01026976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009202837331452735,"score_gpt":0.2430574477701097,"score_spread":0.233854610438657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}