{"id":"W2582286477","doi":"10.1016/s1470-2045(17)30064-5","title":"Buparlisib and paclitaxel in patients with platinum-pretreated recurrent or metastatic squamous cell carcinoma of the head and neck (BERIL-1): a randomised, double-blind, placebo-controlled phase 2 trial","year":2017,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":219,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Internal medicine; Placebo; Regimen; Clinical endpoint; Oncology; Chemotherapy; Phases of clinical research; Response Evaluation Criteria in Solid Tumors; Clinical trial; Head and neck squamous-cell carcinoma; Paclitaxel; Surgery; Head and neck cancer; Radiation therapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007083409,0.0002267075,0.0007830232,0.000033458,0.0001838675,0.00003738397,0.0003945656,0.0001386804,0.00001683243],"category_scores_gemma":[0.0003166223,0.0001143121,0.00007234619,0.00005394842,0.0004129216,0.000008713456,0.0001783144,0.0002047472,5.560299e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003913697,"about_ca_system_score_gemma":0.0002232924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001396481,"about_ca_topic_score_gemma":0.0007572502,"domain_scores_codex":[0.9983708,0.0004155859,0.0003983015,0.0003470962,0.0001518718,0.0003163663],"domain_scores_gemma":[0.9983411,0.0002540601,0.0005504658,0.0007041871,0.00008546723,0.00006466878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9825686,0.000453733,0.0123006,0.00004634405,0.0001001344,0.000006525812,0.0002746071,0.00001964962,0.002811611,0.000009602695,0.0002402153,0.001168354],"study_design_scores_gemma":[0.979642,0.007648066,0.005564186,0.00003120159,0.0002139988,0.000008197683,0.00004720756,0.0001216795,0.005868883,0.00002943152,0.0006550661,0.0001700741],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952439,0.0005871544,0.00001262978,0.0002549468,0.0002671199,0.002848925,0.0000782913,0.000004712456,0.0007023164],"genre_scores_gemma":[0.999025,0.00004709604,0.000140267,0.0001045039,0.0001897319,0.0003278186,0.00002563238,0.00002094879,0.0001190381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007194333,"threshold_uncertainty_score":0.4661514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04651944937229081,"score_gpt":0.3421933897887764,"score_spread":0.2956739404164856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}