{"id":"W2582367431","doi":"10.1038/cddiscovery.2016.100","title":"Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling","year":2017,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Liver physiology and pathology","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Université de Sherbrooke","keywords":"Retromer; Sorting nexin; Hepatocyte growth factor; Cell biology; Hepatocyte; Chemistry; Proteolysis; Receptor; Endosome; Biology; Biochemistry; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000172825,0.0002893636,0.0001951945,0.0002096091,0.00009597539,0.0002484171,0.0001579705,0.0002854276,0.001784716],"category_scores_gemma":[0.0001219431,0.000112889,0.0002876952,0.0001070791,0.0001866996,0.0001528615,0.0001882167,0.000581285,0.00037862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002950947,"about_ca_system_score_gemma":0.0001326371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002559073,"about_ca_topic_score_gemma":0.000398074,"domain_scores_codex":[0.9998211,0.0000435613,0.00002106961,0.00002407751,0.00004408807,0.00004602289],"domain_scores_gemma":[0.9998769,0.00002481069,0.00003364168,0.00001707956,0.000009556456,0.00003813098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001919001,0.00005690023,0.00007631249,0.00002235371,0.000006349287,0.00005996168,0.000005861332,0.00005055954,0.999082,0.00006697341,0.00003364752,0.0003473505],"study_design_scores_gemma":[0.00004470621,0.0005684404,0.001854924,0.000004528617,0.000009257977,0.0003231032,0.00001876609,0.00113747,0.9948387,0.0000382122,0.001158608,0.000003325141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966651,0.0007126325,0.001138685,0.00009519243,0.00003997187,0.0000266262,0.0002997925,0.00005510492,0.0009669883],"genre_scores_gemma":[0.9969559,0.0002603222,0.0008941729,0.00004086577,0.00000741335,0.00002359195,0.0004061842,0.000008465875,0.001403206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001784716,"threshold_uncertainty_score":0.005970478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0243130663277454,"score_gpt":0.2628069418580147,"score_spread":0.2384938755302693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}