{"id":"W2582369321","doi":"10.1038/srep41382","title":"Behavioural Effects of Using Sulfasalazine to Inhibit Glutamate Released by Cancer Cells: A Novel target for Cancer-Induced Depression","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University","funders":"Canadian Institutes of Health Research; Cure Brain Cancer Foundation; McMaster University","keywords":"Anhedonia; Pharmacology; Medicine; Cancer; Sulfasalazine; Behavioural despair test; Fluoxetine; Antidepressant; Anxiolytic; Immunology; Internal medicine; Receptor; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008684173,0.0002812012,0.000269181,0.0001349099,0.00008923082,0.000149926,0.0001878406,0.0002139467,0.0009388452],"category_scores_gemma":[0.00004958854,0.00007209466,0.0002810624,0.0001207037,0.0001605409,0.0001044996,0.00009866125,0.0005543684,0.0001426316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000166909,"about_ca_system_score_gemma":0.0001714028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008635663,"about_ca_topic_score_gemma":0.002279454,"domain_scores_codex":[0.9999578,0.000007535083,0.00000407146,0.000006075785,0.00001108739,0.00001347613],"domain_scores_gemma":[0.9999664,0.000004820673,0.00001106371,0.000004639446,0.000005061098,0.000008098139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003220956,0.00009118098,0.0003205924,0.00008965621,0.00001670098,0.00003664572,0.000008271471,0.00007281613,0.9958655,0.00003482492,0.00005935953,0.003082415],"study_design_scores_gemma":[0.0001683803,0.009269456,0.01662181,0.00002109513,0.00008695508,0.0003806629,0.00005764589,0.001150783,0.9694679,0.00004751885,0.002718947,0.000008936587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937721,0.004149408,0.000900346,0.0001685416,0.00004077953,0.00004712879,0.0002282903,0.00004342698,0.000650058],"genre_scores_gemma":[0.9949453,0.00293296,0.000967661,0.00005763262,0.00001159603,0.00003110016,0.0002196819,0.000002957801,0.0008309789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009388452,"threshold_uncertainty_score":0.003140688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04692904044075131,"score_gpt":0.3186372693788431,"score_spread":0.2717082289380918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}