{"id":"W2582434768","doi":"10.1182/blood.v116.21.2981.2981","title":"Second Clones In Molecularly-Defined Biclonal Multiple Myeloma Are Derived From Unrelated B Cells, Can Be Present at High Frequency and Exhibit Chromosomal Abnormalities","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"clone (Java method); Isotype; Biology; Molecular biology; Immunoglobulin class switching; Monoclonal; Somatic hypermutation; Complementarity determining region; Immunoglobulin light chain; Genetics; Virology; Antibody; Monoclonal antibody; Gene; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002553553,0.0002929656,0.0002148011,0.000669252,0.0002249412,0.0003118936,0.0001973737,0.00032754,0.005277087],"category_scores_gemma":[0.0003721435,0.000173668,0.0001963005,0.0003660264,0.0002177868,0.0001262024,0.0003585609,0.0003749993,0.001078561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002296183,"about_ca_system_score_gemma":0.0001395559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000305257,"about_ca_topic_score_gemma":0.0005796393,"domain_scores_codex":[0.9997236,0.00003950867,0.00003063657,0.0000804685,0.00007602303,0.00004970724],"domain_scores_gemma":[0.9996948,0.0001121749,0.00006390222,0.00004797758,0.00003253361,0.00004865807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001174508,0.00021232,0.09611034,0.0002594318,0.00005803613,0.001672981,0.0002183566,0.0001274311,0.8682877,0.0005067365,0.0005656382,0.03080644],"study_design_scores_gemma":[0.0001819145,0.00291523,0.4853602,0.00007033651,0.000151244,0.03147929,0.0002605201,0.001689603,0.451232,0.0003670783,0.02627506,0.0000173951],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932659,0.0007556198,0.003064461,0.00003441823,0.00002064712,0.00007926772,0.0002691399,0.00008694165,0.00242365],"genre_scores_gemma":[0.9920942,0.0002289691,0.003354776,0.00008355225,0.00001652875,0.0001052211,0.001058654,0.00002962109,0.003028388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005277087,"threshold_uncertainty_score":0.01765364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333439101390071,"score_gpt":0.2308642471989611,"score_spread":0.2175298561850604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}