{"id":"W2582670523","doi":"","title":"Small molecule inhibition of CBP/catenin interactions eliminates drug resistant clones in acute lymphoblastic leukemia","year":2014,"lang":"en","type":"article","venue":"PMC","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Wnt signaling pathway; Chromatin immunoprecipitation; Coactivator; CREB-binding protein; Beta-catenin; Cancer research; Survivin; Biology; Myeloid leukemia; Catenin; Progenitor cell; Cell biology; Signal transduction; Stem cell; CREB; Transcription factor; Genetics; Apoptosis; Gene; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003844374,0.0002157439,0.0004348313,0.0004539358,0.00005766782,0.00002060593,0.0001444447,0.0001020033,0.00009703566],"category_scores_gemma":[0.000668671,0.0001913296,0.0001120073,0.0005150695,0.0001725504,0.0001085841,0.0001287346,0.0002798215,0.0001380232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001350843,"about_ca_system_score_gemma":0.000543598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006573895,"about_ca_topic_score_gemma":0.0002632817,"domain_scores_codex":[0.9981098,0.0001328934,0.000547474,0.000379368,0.0003964935,0.0004340387],"domain_scores_gemma":[0.9985468,0.0005142388,0.0001527339,0.0003765587,0.0002344421,0.0001752496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002320576,0.0004318467,0.006482561,0.0005398805,0.0001751974,0.0003214604,0.001560348,0.0001193128,0.9808084,0.001214635,0.00352569,0.002500057],"study_design_scores_gemma":[0.008124222,0.0007058542,0.04955592,0.001496375,0.0003153052,0.0002490478,0.0005674539,0.01871772,0.9180287,0.0007141856,0.001110794,0.0004144768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940519,0.00009848851,0.001186995,0.0009565327,0.0001263322,0.0003300033,0.00001725747,0.00006618947,0.003166354],"genre_scores_gemma":[0.9961827,0.00007556765,0.001554654,0.0001447631,0.00009906942,0.00006560999,0.00006200355,0.000045671,0.00176994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06277978,"threshold_uncertainty_score":0.7802194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533548247006616,"score_gpt":0.2686224346561769,"score_spread":0.2532869521861107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}