{"id":"W2582670523","doi":"","title":"Small molecule inhibition of CBP/catenin interactions eliminates drug resistant clones in acute lymphoblastic leukemia","year":2014,"lang":"en","type":"article","venue":"PMC","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Wnt signaling pathway; Chromatin immunoprecipitation; Coactivator; CREB-binding protein; Beta-catenin; Cancer research; Survivin; Biology; Myeloid leukemia; Catenin; Progenitor cell; Cell biology; Signal transduction; Stem cell; CREB; Transcription factor; Genetics; Apoptosis; Gene; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001144534,0.0003243079,0.0003880461,0.0003576347,0.0001384815,0.0003486141,0.0002413439,0.0001643988,0.001074464],"category_scores_gemma":[0.00008891662,0.0001501247,0.0001612021,0.0003293504,0.0001771774,0.0001167561,0.0001368144,0.0007270284,0.0003671467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003393076,"about_ca_system_score_gemma":0.0002519423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007803039,"about_ca_topic_score_gemma":0.001694627,"domain_scores_codex":[0.9998757,0.00001570259,0.00001234942,0.00001928037,0.00004278803,0.00003418602],"domain_scores_gemma":[0.9999397,0.00001218653,0.00001334422,0.000009716756,0.000005037147,0.0000200231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008793191,0.0001093731,0.0002159027,0.00003425913,0.000005989711,0.00003173489,0.0000192509,0.00009260185,0.9959965,0.00008711076,0.00007116314,0.003248195],"study_design_scores_gemma":[0.00004502129,0.0008239964,0.004420614,0.000005604725,0.00002998613,0.0002262239,0.00002011782,0.0006401503,0.9903738,0.00002317045,0.003387394,0.000003907862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955679,0.001551711,0.0009392478,0.00006592021,0.00002075821,0.00005522851,0.0002241555,0.0001153975,0.001459665],"genre_scores_gemma":[0.9943308,0.00156244,0.001085331,0.00004387182,0.000006657395,0.00005147796,0.0006029442,0.00001997122,0.002296589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001074464,"threshold_uncertainty_score":0.003594458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533548247006616,"score_gpt":0.2686224346561769,"score_spread":0.2532869521861107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}