{"id":"W2583158916","doi":"10.1002/biot.201600678","title":"<i>Streptomyces venezuelae</i> TX‐TL – a next generation cell‐free synthetic biology tool","year":2017,"lang":"en","type":"article","venue":"Biotechnology Journal","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kensington Health","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Imperial College London","keywords":"Synthetic biology; Streptomyces; Biology; TetR; Repressor; Bioproduction; Metabolic engineering; Biochemistry; Protein biosynthesis; Computational biology; Chemistry; Enzyme; Gene; Gene expression; Genetics; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473587,0.000369108,0.0001680596,0.0002443509,0.0002053266,0.0003534394,0.0001937882,0.0001578922,0.001765023],"category_scores_gemma":[0.000127506,0.0001274505,0.0001726387,0.0002398499,0.0001642262,0.000219706,0.0002550183,0.0004628029,0.0009942742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003182613,"about_ca_system_score_gemma":0.000259177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004181,"about_ca_topic_score_gemma":0.002077146,"domain_scores_codex":[0.9998915,0.00001857603,0.000008576811,0.00002875027,0.00003403565,0.00001850065],"domain_scores_gemma":[0.9999495,0.000008144828,0.00001598452,0.00001206093,0.000005754689,0.000008681395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003916259,0.00001077307,0.0001474716,0.00005624556,0.000002039401,0.00006094136,0.0000162151,0.00008752154,0.994733,0.0003909714,0.0001631333,0.004292642],"study_design_scores_gemma":[0.000006352506,0.0001114229,0.001215497,0.00001145537,0.000007276769,0.0003810055,0.00002075111,0.0004164232,0.9753125,0.0001054257,0.02240335,0.000008419581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8736309,0.006525239,0.08471148,0.0007411495,0.0004496232,0.0002695451,0.003806877,0.002529776,0.02733548],"genre_scores_gemma":[0.9106863,0.002511304,0.06578827,0.0001101703,0.00004067534,0.0001160973,0.005253509,0.0002187687,0.01527496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001765023,"threshold_uncertainty_score":0.005904555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0331028807178683,"score_gpt":0.2662221024781155,"score_spread":0.2331192217602472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}