{"id":"W2583374965","doi":"10.1128/jvi.02442-16","title":"HIV-1 Vpu Downmodulates ICAM-1 Expression, Resulting in Decreased Killing of Infected CD4 <sup>+</sup> T Cells by NK Cells","year":2017,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Ubiquitin ligase; Downregulation and upregulation; Biology; Cell biology; Ubiquitin; Transmembrane protein; Molecular biology; Biochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000749395,0.0002855427,0.000269916,0.0001594305,0.0001096174,0.000350002,0.0001998832,0.0001789822,0.001506458],"category_scores_gemma":[0.00008906692,0.00009673138,0.0001618548,0.00009473178,0.0001816545,0.0001477615,0.0001262667,0.0005839961,0.00030572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001703022,"about_ca_system_score_gemma":0.0001024247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002545937,"about_ca_topic_score_gemma":0.0003087219,"domain_scores_codex":[0.9998809,0.00002211091,0.00001489678,0.00001818714,0.00002376121,0.00004012702],"domain_scores_gemma":[0.9999441,0.00001250283,0.00001165906,0.000008543839,0.00000538186,0.00001785562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001395924,0.00004250708,0.00007360649,0.00001717749,0.000002518858,0.00002071774,0.000004677676,0.00002580162,0.9989685,0.00002761871,0.00002479577,0.000652551],"study_design_scores_gemma":[0.00001623013,0.0005257429,0.002697663,0.000003623008,0.00000958947,0.0001092033,0.00001589424,0.0004282815,0.9953968,0.00002005451,0.0007750615,0.000001838481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980587,0.0006209649,0.0003960124,0.00004481555,0.00002430937,0.00001281725,0.000203329,0.00004276611,0.0005963278],"genre_scores_gemma":[0.9970334,0.0003592605,0.0006307588,0.00004160765,0.00001320307,0.00002448679,0.0003461792,0.00001621959,0.001534877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001506458,"threshold_uncertainty_score":0.005039573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008706928730798136,"score_gpt":0.2365625582691132,"score_spread":0.227855629538315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}