{"id":"W2583383492","doi":"10.1182/blood.v108.11.1954.1954","title":"Phase I/II Study of the Oral Isotype-Selective Histone Deacetylase (HDAC) Inhibitor MGCD0103 in Combination with Azacitidine in Patients (pts) with High-Risk Myelodysplastic Syndrome (MDS) or Acute Myelogenous Leukemia (AML).","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Azacitidine; Medicine; Internal medicine; Myelodysplastic syndromes; Leukemia; Gastroenterology; Oncology; Pharmacology; Bone marrow; DNA methylation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001093478,0.001547882,0.002254245,0.0005319387,0.0004704235,0.000890519,0.001070627,0.0012408,0.003117004],"category_scores_gemma":[0.000566516,0.0006768436,0.001182866,0.0005179585,0.001096573,0.0006869694,0.0004482054,0.003243212,0.0009999983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007611503,"about_ca_system_score_gemma":0.001767332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001130861,"about_ca_topic_score_gemma":0.002100264,"domain_scores_codex":[0.9996338,0.0001519922,0.00001742776,0.00007398245,0.00003632974,0.00008651966],"domain_scores_gemma":[0.9995459,0.00005357479,0.00005942196,0.00004417432,0.00002656749,0.000270366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.606446,0.1817351,0.007887505,0.0008724267,0.001043589,0.000522015,0.0004231303,0.003137841,0.08939628,0.0005261709,0.00453218,0.1034777],"study_design_scores_gemma":[0.3341183,0.6484945,0.007508525,0.00002320451,0.0003122522,0.0002487227,0.00006028088,0.0009181543,0.005429024,0.0001728947,0.002689493,0.00002465749],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896106,0.001955746,0.0008090042,0.0003941464,0.0001588545,0.004138185,0.000955089,0.0001069666,0.001871333],"genre_scores_gemma":[0.9845973,0.002170417,0.0027631,0.0008724366,0.0002355086,0.004055221,0.001969016,0.00004577291,0.003291408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003117004,"threshold_uncertainty_score":0.01042742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004730626248085849,"score_gpt":0.2350056433771064,"score_spread":0.2302750171290206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}