{"id":"W2583554616","doi":"10.1016/j.bpj.2016.11.1128","title":"smFRET Reveals Structural Basis for Conformational Misfolding of a Cystic Fibrosis Mutation in CFTR","year":2017,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Cystic fibrosis transmembrane conductance regulator; Single-molecule FRET; Mutation; Protein folding; Membrane protein; Chemistry; Population; Helix (gastropod); Biophysics; Biology; Transmembrane protein; Transmembrane domain; Förster resonance energy transfer; Genetics; Cell biology; Cystic fibrosis; Membrane; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004435223,0.0005163107,0.0004809911,0.0003819038,0.0006426277,0.0004364946,0.000625431,0.001300936,0.002786304],"category_scores_gemma":[0.0008787359,0.0002226016,0.000799975,0.000249966,0.0004651022,0.0004475999,0.0003680942,0.001801132,0.0006400254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005713217,"about_ca_system_score_gemma":0.0003317334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00194167,"about_ca_topic_score_gemma":0.0018988,"domain_scores_codex":[0.9997802,0.00003430748,0.00001975951,0.00005263298,0.00006855535,0.00004453444],"domain_scores_gemma":[0.9993448,0.0002045334,0.0001741104,0.0000648574,0.00008029079,0.0001314117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006183175,0.0001381949,0.004916574,0.000110083,0.00007272902,0.009967184,0.0002623902,0.002602091,0.9710267,0.001943924,0.002095215,0.006246588],"study_design_scores_gemma":[0.0001550315,0.0007452917,0.0482096,0.00007041776,0.0001736866,0.01947581,0.0004265908,0.04686723,0.8722045,0.001762512,0.009738359,0.0001710278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925596,0.0004542853,0.003889362,0.0008838565,0.0002362911,0.00001821983,0.000484207,0.0002512101,0.001223114],"genre_scores_gemma":[0.9966702,0.0001082178,0.001725948,0.000312632,0.00004047316,0.00001038221,0.0004587761,0.00007040129,0.0006030257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002786304,"threshold_uncertainty_score":0.009321153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02636889617055177,"score_gpt":0.3517634385898141,"score_spread":0.3253945424192624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}