{"id":"W2583669122","doi":"10.2147/dddt.s121518","title":"&lt;em&gt;Kelussia odoratissima&lt;/em&gt; Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement of p21/p27 in vitro and in vivo","year":2017,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Plant chemical constituents analysis","field":"Agricultural and Biological Sciences","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Apoptosis; MCF-7; Cell cycle checkpoint; Programmed cell death; MTT assay; Cell cycle; In vivo; Chemistry; Cancer research; Cell growth; Annexin; Cytotoxicity; Cancer cell; Cancer; In vitro; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000547249,0.0003373654,0.0002197362,0.0004019342,0.000225171,0.0001139624,0.0001157151,0.0001951031,0.002103576],"category_scores_gemma":[0.00004579503,0.00007252335,0.0002362216,0.0002240991,0.0001436192,0.0001697448,0.000155352,0.0003147985,0.0004394733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001885715,"about_ca_system_score_gemma":0.0001774627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009415092,"about_ca_topic_score_gemma":0.001662084,"domain_scores_codex":[0.999966,0.000003958643,0.000003058594,0.00000638276,0.00001081174,0.0000096933],"domain_scores_gemma":[0.9999678,0.000003768066,0.00001185243,0.000002646901,0.000008020247,0.000006032515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004362654,0.0001328523,0.001231475,0.0004434155,0.00002191594,0.0003166961,0.0000337034,0.0001448322,0.9757976,0.0001821219,0.0002672723,0.02099196],"study_design_scores_gemma":[0.0001604547,0.002292622,0.09617336,0.0001281862,0.0001819952,0.004228262,0.0001932074,0.001269509,0.8653637,0.0006260598,0.02935394,0.00002882484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827382,0.005912766,0.002298271,0.0003258529,0.00005655134,0.00004252195,0.0005475982,0.0001698607,0.007908482],"genre_scores_gemma":[0.9909046,0.0021612,0.00187002,0.0001697358,0.00002489095,0.00002235534,0.0004559997,0.00001603229,0.004375156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002103576,"threshold_uncertainty_score":0.007037163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629617305963993,"score_gpt":0.2128400323415158,"score_spread":0.1965438592818759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}