{"id":"W2583669122","doi":"10.2147/dddt.s121518","title":"<em>Kelussia odoratissima</em> Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement of p21/p27 in vitro and in vivo","year":2017,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Plant chemical constituents analysis","field":"Agricultural and Biological Sciences","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Apoptosis; MCF-7; Cell cycle checkpoint; Programmed cell death; MTT assay; Cell cycle; In vivo; Chemistry; Cancer research; Cell growth; Annexin; Cytotoxicity; Cancer cell; Cancer; In vitro; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004439844,0.0002465296,0.0004926272,0.00008206778,0.0001152064,0.00007223529,0.0002510119,0.00009897396,0.00006014507],"category_scores_gemma":[0.00001139742,0.0001157981,0.00003265152,0.0003270764,0.0001229654,0.0002088936,0.0000685323,0.000119171,4.191575e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007820453,"about_ca_system_score_gemma":0.00005524218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006342652,"about_ca_topic_score_gemma":0.003618806,"domain_scores_codex":[0.9985196,0.0001076881,0.0004360392,0.000365998,0.0002700675,0.0003006243],"domain_scores_gemma":[0.999229,0.0001663495,0.0003725366,0.00008200817,0.0000586492,0.00009150439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005417435,0.0005176225,0.02852556,0.00001293961,0.00005518044,0.000006745345,0.0007747596,0.0000116472,0.9235999,0.000001813706,0.00001598144,0.04593612],"study_design_scores_gemma":[0.001878692,0.00003479252,0.06858897,0.0001650966,0.000009283594,3.256232e-7,0.0001531428,0.0001457048,0.9286424,0.00004508112,0.00008397828,0.0002525297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990482,0.0003070788,0.000008072024,0.0001518515,0.00002379531,0.0003316736,0.00008548937,0.000009197691,0.00003468931],"genre_scores_gemma":[0.9987712,0.0008055448,0.0002589143,0.00004261627,0.00001199146,0.00004236209,0.0000379378,0.000002772713,0.00002667025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04568359,"threshold_uncertainty_score":0.4722108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629617305963993,"score_gpt":0.2128400323415158,"score_spread":0.1965438592818759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}